Evaluation of central nervous conduction by visual evoked potentials in insulin-dependent diabetic children. metabolic and clinical correlations

Giancarlo Comi, Vittorio Martinelli, Giuseppe Galardi, Stefania Medaglini, Luciano Beccaria, Franco Meschi, Luca Rosti, Nadia Bressani, Giuseppe Chiumello

Research output: Contribution to journalArticle

Abstract

Peripheral neuropathy is a well-known complication of diabetes, but few data are available on central lesions. Visual evoked potentials (VEPs) seem a reliable and feasible technique for detecting a conduction delay in the central nervous, system. Seventy-one insulin-dependent type 1 diabetic children (mean age 15±3 years) and 33 controls were investigated for central neuropathy. We used a pattern of reversal stimulation with television display of a checker board pattern (15 min and 30 min check size). The latencies of the positive peak (P100 wave) were significantly lengthened in 17 patients (27%) but no correlation was found between VEPs and age, duration of diabetes, insulin requirement and HbA1 level. A negative correlation was found between VEPs and peripheral nervous conduction velocity. VEPs measurement seems a simple and reliable technique for detecting early alterations in CNS function in diabetics. Our data suggest that central and peripheral nervous alterations progress simultaneously.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalActa Diabetologica Latina
Volume24
Issue number2
DOIs
Publication statusPublished - Apr 1987

Keywords

  • Diabetic complications
  • Type I diabetes
  • Visual evoked potentials

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Evaluation of central nervous conduction by visual evoked potentials in insulin-dependent diabetic children. metabolic and clinical correlations'. Together they form a unique fingerprint.

  • Cite this