Evaluation of chlorhexidine 0.05% with the adjunct of fluoride 0.05% in the inhibition of plaque formation: A double blind, crossover, plaque regrowth study

F. De Siena, M. Del Fabbro, S. Corbella, S. Taschieri, R. Weinstein

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim of this study was to evaluate the effect of mouthrinses containing 0.05% chlorhexidine + 0.05% fluoride solution on early dental plaque regrowth. Materials and methods: Thirty periodontally healthy subjects were included in the study. A crossover 4-day plaque regrowth protocol was adopted. The test product was initially used in 15 patients, while a placebo was administered to the other 15 patients. Then, after a washout period, each patient used the other product. No other oral hygiene manoeuvre was allowed. Full-mouth plaque and bleeding scores (FMPS and FMBS) were evaluated at baseline and after 4 days. Results: All subjects completed the study. The mean age was 27 ± 8.4 years. Five patients were smokers with a mean daily consumption of 1 ± 2.5 cigarettes. FMPS at baseline was 8.0 ± 4.4 for control group and 7.9 ± 3.8 for test group, without significant difference. After the 4-day plaque regrowth the mean FMPS significantly increased to 31.9 ± 16.5 and 36.3 ± 16.1 for control and test group, respectively (no significant difference between the two groups). Conclusions: The test product was safe and well tolerated by subjects. The similar outcomes of the two experimental groups suggest that the two products have an equivalent effect on early dental plaque regrowth. Studies with longer follow-up are needed to clarify whether there is a beneficial long-term effect of daily rinses with the tested solution.

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalInternational Journal of Dental Hygiene
Volume11
Issue number3
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Bacterial plaque
  • Chlorhexidine
  • Fluoride
  • Gingival inflammation

ASJC Scopus subject areas

  • Dentistry (miscellaneous)

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