Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) using SD-OCT and Angio-OCT

Chiara Del Noce, Aldo Vagge, Massimo Nicolò, Carlo Enrico Traverso

Research output: Contribution to journalArticle


Purpose: The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) and their relationship with clinical features and disease activity using spectral domain optical coherence tomography (SD-OCT) and Angio-OCT technology. Methods: Eighteen patients and control subjects underwent a complete eye examination, OCT, and Angio-OCT. We also obtained angiographic scans at 3 different consecutive levels (L1, L2, and L3) below the choriocapillary. Results: The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared with 135.89 ± 19.8 μm, respectively, p = 0.0089). The correlation analysis in the TAO group showed a significant correlation between the choroidal thickness and EUGOGO clinical score (r = 0.84, p = 8.44032E-07). Vascular flow of choriocapillary was markedly reduced in subjects with TAO compared with healthy subjects (49.78 ± 4.5 vs. 53.36 ± 1.07; p = 2.5105E-07) and vascular flow of the deeper layer L3 resulted higher in subjects with TAO than in healthy subjects (46.9 ± 20.23 and 41.475 ± 3.06; p = 0.01168). Conclusions: Subfoveal choroidal thickness and choroidal blood flow were significantly different in patients with TAO compared with healthy subjects.

Original languageEnglish
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Publication statusAccepted/In press - Jan 1 2020



  • Angio-OCT
  • Choroid
  • OCT
  • Orbitopathy
  • Thyroid

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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