Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: A pilot observational study

Emanuela Galliera, Monica Gioia Marazzi, Carmine Gazzaruso, Pietro Gallotti, Adriana Coppola, Tiziana Montalcini, Arturo Pujia, Massimiliano M. Corsi Romanelli

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE). The aim of this study is to investigate the potential role of circulating sRAGE in osteoporosis, in particular evaluating the correlation of sRAGE with the fracture risk, in association with bone mineral density, the fracture risk marker FGF23, and lipid metabolism. Results: Circulating level of soluble RAGE correlate with osteopenia and osteoporosis level. Serum sRAGE resulted clearly associated on the one hand to bone fragility and, on the other hand, with BMI and leptin. sRAGE is particularly informative because serum sRAGE is able to provide, as a single marker, information about both the aspects of osteoporotic disease, represented by bone fragility and lipid metabolism. Conclusions: The measure serum level of sRAGE could have a potential diagnostic role in the monitoring of osteoporosis progression, in particular in the evaluation of fracture risk, starting from the prevention and screening stage, to the osteopenic level to osteoporosis.

Original languageEnglish
Article number13
JournalImmunity and Ageing
Volume14
Issue number1
DOIs
Publication statusPublished - Jun 14 2017

Fingerprint

Adipokines
Osteoporosis
Observational Studies
Lipid Metabolism
Bone and Bones
Serum
Hand Bones
Bone Remodeling
Metabolic Bone Diseases
Bone Diseases
Metabolic Diseases
Bone Resorption
Leptin
Osteogenesis
Bone Density
Oxidative Stress
Proteins

Keywords

  • Circulating RAGE
  • Fracture risk
  • Glycation end products
  • Osteoporosis

ASJC Scopus subject areas

  • Immunology
  • Ageing

Cite this

Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk : A pilot observational study. / Galliera, Emanuela; Marazzi, Monica Gioia; Gazzaruso, Carmine; Gallotti, Pietro; Coppola, Adriana; Montalcini, Tiziana; Pujia, Arturo; Corsi Romanelli, Massimiliano M.

In: Immunity and Ageing, Vol. 14, No. 1, 13, 14.06.2017.

Research output: Contribution to journalArticle

Galliera, Emanuela ; Marazzi, Monica Gioia ; Gazzaruso, Carmine ; Gallotti, Pietro ; Coppola, Adriana ; Montalcini, Tiziana ; Pujia, Arturo ; Corsi Romanelli, Massimiliano M. / Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk : A pilot observational study. In: Immunity and Ageing. 2017 ; Vol. 14, No. 1.
@article{706f3612808e4b4ca4c1315254e3bbb8,
title = "Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: A pilot observational study",
abstract = "Background: Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE). The aim of this study is to investigate the potential role of circulating sRAGE in osteoporosis, in particular evaluating the correlation of sRAGE with the fracture risk, in association with bone mineral density, the fracture risk marker FGF23, and lipid metabolism. Results: Circulating level of soluble RAGE correlate with osteopenia and osteoporosis level. Serum sRAGE resulted clearly associated on the one hand to bone fragility and, on the other hand, with BMI and leptin. sRAGE is particularly informative because serum sRAGE is able to provide, as a single marker, information about both the aspects of osteoporotic disease, represented by bone fragility and lipid metabolism. Conclusions: The measure serum level of sRAGE could have a potential diagnostic role in the monitoring of osteoporosis progression, in particular in the evaluation of fracture risk, starting from the prevention and screening stage, to the osteopenic level to osteoporosis.",
keywords = "Circulating RAGE, Fracture risk, Glycation end products, Osteoporosis",
author = "Emanuela Galliera and Marazzi, {Monica Gioia} and Carmine Gazzaruso and Pietro Gallotti and Adriana Coppola and Tiziana Montalcini and Arturo Pujia and {Corsi Romanelli}, {Massimiliano M.}",
year = "2017",
month = "6",
day = "14",
doi = "10.1186/s12979-017-0097-0",
language = "English",
volume = "14",
journal = "Immunity and Ageing",
issn = "1742-4933",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk

T2 - A pilot observational study

AU - Galliera, Emanuela

AU - Marazzi, Monica Gioia

AU - Gazzaruso, Carmine

AU - Gallotti, Pietro

AU - Coppola, Adriana

AU - Montalcini, Tiziana

AU - Pujia, Arturo

AU - Corsi Romanelli, Massimiliano M.

PY - 2017/6/14

Y1 - 2017/6/14

N2 - Background: Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE). The aim of this study is to investigate the potential role of circulating sRAGE in osteoporosis, in particular evaluating the correlation of sRAGE with the fracture risk, in association with bone mineral density, the fracture risk marker FGF23, and lipid metabolism. Results: Circulating level of soluble RAGE correlate with osteopenia and osteoporosis level. Serum sRAGE resulted clearly associated on the one hand to bone fragility and, on the other hand, with BMI and leptin. sRAGE is particularly informative because serum sRAGE is able to provide, as a single marker, information about both the aspects of osteoporotic disease, represented by bone fragility and lipid metabolism. Conclusions: The measure serum level of sRAGE could have a potential diagnostic role in the monitoring of osteoporosis progression, in particular in the evaluation of fracture risk, starting from the prevention and screening stage, to the osteopenic level to osteoporosis.

AB - Background: Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE). The aim of this study is to investigate the potential role of circulating sRAGE in osteoporosis, in particular evaluating the correlation of sRAGE with the fracture risk, in association with bone mineral density, the fracture risk marker FGF23, and lipid metabolism. Results: Circulating level of soluble RAGE correlate with osteopenia and osteoporosis level. Serum sRAGE resulted clearly associated on the one hand to bone fragility and, on the other hand, with BMI and leptin. sRAGE is particularly informative because serum sRAGE is able to provide, as a single marker, information about both the aspects of osteoporotic disease, represented by bone fragility and lipid metabolism. Conclusions: The measure serum level of sRAGE could have a potential diagnostic role in the monitoring of osteoporosis progression, in particular in the evaluation of fracture risk, starting from the prevention and screening stage, to the osteopenic level to osteoporosis.

KW - Circulating RAGE

KW - Fracture risk

KW - Glycation end products

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=85020695720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020695720&partnerID=8YFLogxK

U2 - 10.1186/s12979-017-0097-0

DO - 10.1186/s12979-017-0097-0

M3 - Article

AN - SCOPUS:85020695720

VL - 14

JO - Immunity and Ageing

JF - Immunity and Ageing

SN - 1742-4933

IS - 1

M1 - 13

ER -