Evaluation of clinical and ultrasonographic parameters in psoriatic arthritis patients treated with adalimumab: A retrospective study

M. Teoli, A. Zangrilli, M. S. Chimenti, M. Talamonti, M. Bavetta, D. Graceffa, R. Perricone, S. Chimenti

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Abstract

Objectives. The aim of this study was to evaluate clinical and US-PD parameters in PsA during adalimumab treatment. Methods. A retrospective study has been conducted in forty patients affected by moderate-to-severe peripheral PsA. Clinical, laboratory, and US-PD evaluations were performed at baseline, after 4, 12, and 24 weeks of treatment. They included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), visual analogue scale (VAS), Health Assessment Questionnaire (HAQ) modified for Spondyloarthritis, Psoriasis Area Severity Index (PASI) score, the 28-joint Disease Activity Score (DAS 28), and US-PD assessment. US-PD findings were scored according to a semiquantitative scale (ranging 0-3) for synovial proliferation (SP), joint effusion (SE), bone erosions (BE), and PD. Results. Data obtained for clinical, laboratory findings and US-PD evaluation showed statistical significant improvement in all the measures performed except for BE. A significant parallel decrease in SE, SP, and PD values were demonstrated. Conclusion. This study demonstrated that US-PD is a valid technique in monitoring the response to adalimumab in moderate-to-severe PsA.

Original languageEnglish
Article number823854
JournalClinical and Developmental Immunology
Volume2012
DOIs
Publication statusPublished - 2012

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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