Evaluation of current methods for the measurement of serum anti-double-stranded DNA antibodies

Anna Ghirardello, Danilo Villalta, Gabriella Morozzi, Antonella Afeltra, Mauro Galeazzi, Roberto Gerli, Alessandro Mathieu, Pier Luigi Meroni, Paola Migliorini, Antonella Radice, Valeria Riccieri, Amelia Ruffatti, Gian Domenico Sebastiani, Angela Tincani, Andrea Doria

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Autoantibodies to double-stranded DNA (dsDNA) are, by definition, serological markers of systemic lupus erythematosus. However, the clinical value of anti-dsDNA antibodies largely depends on the assay principle and analytical variables of the methods used to quantitate and immunologically characterize them. In the present article, an overview of current methods for anti-dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages401-406
Number of pages6
Volume1109
DOIs
Publication statusPublished - Aug 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1109
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Anti-double-stranded DNA antibody
  • Diagnostic accuracy
  • Laboratory methods
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Ghirardello, A., Villalta, D., Morozzi, G., Afeltra, A., Galeazzi, M., Gerli, R., Mathieu, A., Meroni, P. L., Migliorini, P., Radice, A., Riccieri, V., Ruffatti, A., Sebastiani, G. D., Tincani, A., & Doria, A. (2007). Evaluation of current methods for the measurement of serum anti-double-stranded DNA antibodies. In Annals of the New York Academy of Sciences (Vol. 1109, pp. 401-406). (Annals of the New York Academy of Sciences; Vol. 1109). https://doi.org/10.1196/annals.1398.045