Evaluation of damage to DNA after in vivo exposure to different classes of chemicals

C. F. Cesarone, C. Bolognesi, L. Santi

Research output: Contribution to journalArticle

Abstract

Swiss CD1 male mice were injected intraperitoneally (i.p.) with compounds belonging to different chemical classes in order to investigate the influence of those chemicals on the in vivo production of single-strand DNA-breaks in liver and kidney. DNA damage was evaluated by the alkaline elution technique coupled with a microfluorometric method for DNA assay. An increased elution rate was obtained after in vivo treatment with known carcinogens. Our results are in good agreement with the data obtained by long-term carcinogenicity tests and less with those obtained by mutagenicity assays.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalArchives of Toxicology
Volume49
Issue numberSuppl. 5
Publication statusPublished - 1982

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ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Cesarone, C. F., Bolognesi, C., & Santi, L. (1982). Evaluation of damage to DNA after in vivo exposure to different classes of chemicals. Archives of Toxicology, 49(Suppl. 5), 355-359.