Swiss CD1 male mice were injected intraperitoneally (i.p.) with compounds belonging to different chemical classes in order to investigate the influence of those chemicals on the in vivo production of single-strand DNA-breaks in liver and kidney. DNA damage was evaluated by the alkaline elution technique coupled with a microfluorometric method for DNA assay. An increased elution rate was obtained after in vivo treatment with known carcinogens. Our results are in good agreement with the data obtained by long-term carcinogenicity tests and less with those obtained by mutagenicity assays.
|Number of pages||5|
|Journal||Archives of Toxicology|
|Issue number||Suppl. 5|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis