TY - JOUR
T1 - Evaluation of different strategies for identifying asymptomatic left ventricular dysfunction and pre-clinical (stage B) heart failure in the elderly. Results from 'PREDICTOR', a population based-study in central Italy
AU - Mureddu, Gian Francesco
AU - Tarantini, Luigi
AU - Agabiti, Nera
AU - Faggiano, Pompilio
AU - Masson, Serge
AU - Latini, Roberto
AU - Cesaroni, Giulia
AU - Miceli, Maria
AU - Forastiere, Francesco
AU - Scardovi, Angela Beatrice
AU - Uguccioni, Massimo
AU - Boccanelli, Alessandro
PY - 2013/10
Y1 - 2013/10
N2 - AimsTo evaluate the accuracy and cost-effectiveness of different screening strategies to identify systolic and/or diastolic asymptomatic LV dysfunction (ALVD), as well as pre-clinical (stage B) heart failure (HF), in a community of elderly subjects in Italy.Methods and resultsA sample of 1452 subjects aged 65-84 years were chosen from the original cohort of 2001 randomly selected residents of the Lazio Region (Italy), as a part of the PREDICTOR survey. All subjects underwent physical examination, biochemistry/NT-proBNP assessment, 12-lead ECG, and Doppler transthoracic echocardiography (TE). Five strategies were evaluated including ECG, NT-proBNP, TE, and their combinations. Subjects older than 75 years, and with at least two additional risk factors, were defined as being high-risk for HF (435), whereas the remaining 1017 were defined at low risk. Screening characteristics and cost-effectiveness (cost per case) of the five strategies to predict systolic (EF
AB - AimsTo evaluate the accuracy and cost-effectiveness of different screening strategies to identify systolic and/or diastolic asymptomatic LV dysfunction (ALVD), as well as pre-clinical (stage B) heart failure (HF), in a community of elderly subjects in Italy.Methods and resultsA sample of 1452 subjects aged 65-84 years were chosen from the original cohort of 2001 randomly selected residents of the Lazio Region (Italy), as a part of the PREDICTOR survey. All subjects underwent physical examination, biochemistry/NT-proBNP assessment, 12-lead ECG, and Doppler transthoracic echocardiography (TE). Five strategies were evaluated including ECG, NT-proBNP, TE, and their combinations. Subjects older than 75 years, and with at least two additional risk factors, were defined as being high-risk for HF (435), whereas the remaining 1017 were defined at low risk. Screening characteristics and cost-effectiveness (cost per case) of the five strategies to predict systolic (EF
KW - Asymptomatic left ventricular dysfunction
KW - Elderly
KW - Heart failure screening
KW - Heart failure stage B
KW - Prevention
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U2 - 10.1093/eurjhf/hft098
DO - 10.1093/eurjhf/hft098
M3 - Article
C2 - 23787717
AN - SCOPUS:84885026072
VL - 15
SP - 1102
EP - 1112
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 10
ER -