Evaluation of different strategies for identifying asymptomatic left ventricular dysfunction and pre-clinical (stage B) heart failure in the elderly. Results from 'PREDICTOR', a population based-study in central Italy

Gian Francesco Mureddu, Luigi Tarantini, Nera Agabiti, Pompilio Faggiano, Serge Masson, Roberto Latini, Giulia Cesaroni, Maria Miceli, Francesco Forastiere, Angela Beatrice Scardovi, Massimo Uguccioni, Alessandro Boccanelli

Research output: Contribution to journalArticle

Abstract

AimsTo evaluate the accuracy and cost-effectiveness of different screening strategies to identify systolic and/or diastolic asymptomatic LV dysfunction (ALVD), as well as pre-clinical (stage B) heart failure (HF), in a community of elderly subjects in Italy.Methods and resultsA sample of 1452 subjects aged 65-84 years were chosen from the original cohort of 2001 randomly selected residents of the Lazio Region (Italy), as a part of the PREDICTOR survey. All subjects underwent physical examination, biochemistry/NT-proBNP assessment, 12-lead ECG, and Doppler transthoracic echocardiography (TE). Five strategies were evaluated including ECG, NT-proBNP, TE, and their combinations. Subjects older than 75 years, and with at least two additional risk factors, were defined as being high-risk for HF (435), whereas the remaining 1017 were defined at low risk. Screening characteristics and cost-effectiveness (cost per case) of the five strategies to predict systolic (EF

Original languageEnglish
Pages (from-to)1102-1112
Number of pages11
JournalEuropean Journal of Heart Failure
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 2013

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Keywords

  • Asymptomatic left ventricular dysfunction
  • Elderly
  • Heart failure screening
  • Heart failure stage B
  • Prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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