Evaluation of dopaminergic tone in postmenopausal women: Effects of piribedil on anterior pituitary hormones

L. De Marinis, A. Mancini, F. Calabro, R. Sciuto, C. Fiumara, P. Zuppi, A. Saporosi, A. Barini, E. Menini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In order to evaluate the relationships between gonadal steroid hormones and central dopaminergic (DA) tone, we have administered a 'weak' dopamine agonist drug (piribedil) in 12 normal women, who were postmenopausal for at least 5 yrs, and we have studied the effects on anterior pituitary hormone release. We observed a decrease of plasma PRL levels and an increase of plasma GH values with all doses (40, 60, 100 mg p.o.) of the drug employed. No consistent changes in plasma FSH, LH, ACTH and TSH were observed and no side effects were reported. These results were greatly different from those previously described in premenopausal women in whom dose-related effects were observed and were similar to those observed in normal male subjects. The differences in the response to piribedil observed in women before and after the menopause could be due to a different sexual steroid environment.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalHormone and Metabolic Research
Volume23
Issue number1
Publication statusPublished - 1991

Fingerprint

Piribedil
Anterior Pituitary Hormones
Plasmas
Dopamine Agents
Dopamine Agonists
Gonadal Steroid Hormones
Menopause
Pharmaceutical Preparations
Adrenocorticotropic Hormone
Steroids

Keywords

  • dopamine
  • estrogens
  • GH
  • menopause
  • piribedil
  • PRL

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

De Marinis, L., Mancini, A., Calabro, F., Sciuto, R., Fiumara, C., Zuppi, P., ... Menini, E. (1991). Evaluation of dopaminergic tone in postmenopausal women: Effects of piribedil on anterior pituitary hormones. Hormone and Metabolic Research, 23(1), 30-34.

Evaluation of dopaminergic tone in postmenopausal women : Effects of piribedil on anterior pituitary hormones. / De Marinis, L.; Mancini, A.; Calabro, F.; Sciuto, R.; Fiumara, C.; Zuppi, P.; Saporosi, A.; Barini, A.; Menini, E.

In: Hormone and Metabolic Research, Vol. 23, No. 1, 1991, p. 30-34.

Research output: Contribution to journalArticle

De Marinis, L, Mancini, A, Calabro, F, Sciuto, R, Fiumara, C, Zuppi, P, Saporosi, A, Barini, A & Menini, E 1991, 'Evaluation of dopaminergic tone in postmenopausal women: Effects of piribedil on anterior pituitary hormones', Hormone and Metabolic Research, vol. 23, no. 1, pp. 30-34.
De Marinis, L. ; Mancini, A. ; Calabro, F. ; Sciuto, R. ; Fiumara, C. ; Zuppi, P. ; Saporosi, A. ; Barini, A. ; Menini, E. / Evaluation of dopaminergic tone in postmenopausal women : Effects of piribedil on anterior pituitary hormones. In: Hormone and Metabolic Research. 1991 ; Vol. 23, No. 1. pp. 30-34.
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