Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits

Giuliano Mariani, Carla Augeri, Fabio Pretolesi, Eugenio Mereto, Giovanna Curti, Carlo Martinoli, Antonietta Martelli, Lorenzo E. Derchi

Research output: Contribution to journalArticle

Abstract

Rationale and Objectives. Radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. A new method has recently been developed for measuring levels of stable iodine (iodine-127) in biologic samples, based on the detection of x-ray fluorescence photons. In this study, the authors assessed the potential of the new system to evaluate ERPF by using an iodinated contrast medium with adequate glomerular filtration and tubular secretion properties. Materials and Methods. A commercial system was used to evaluate ERPF after intravenous injection of stable I-127 ortho-iodohippurate. The results were compared with the clearance values of I-123 ortho-iodohippurate, considered the reference standard. Seven rabbits under general anesthesia were given intravenous injections of I-123 ortho-iodohippurate and I-127 ortho-iodohippurate. The corresponding plasma curves were evaluated from 4 to 60 minutes to calculate ERPF as the dose/integral of plasma curve. Results. The initial distribution volumes of I-123 ortho-iodohippurate (149.4 mL/kg ± 12.1) and I-127 ortho-iodohippurate (148.8 mL/kg ± 11.8) were virtually superimposable, thus confirming the chemical identity of the two compounds. The plasma clearance values for I-127 ortho-iodohippurate (11.15 mL/min kg-1 ± 1.44) were slightly (not significantly) higher than those for I-123 ortho-iodohippurate (10.49 mL/min kg-1 ± 1.41), perhaps because of a relative 'mass' load effect of the iodinated medium. Conclusion. The results obtained in this study demonstrate the feasibility of the new system for evaluating ERPF, provided that a compound with adequate glomerular filtration and tubular secretion properties is employed.

Original languageEnglish
Pages (from-to)705-710
Number of pages6
JournalAcademic Radiology
Volume7
Issue number9
Publication statusPublished - 2000

Fingerprint

Iodohippuric Acid
Effective Renal Plasma Flow
Rabbits
Intravenous Injections
Iodine
Feasibility Studies
Photons
Radionuclide Imaging
General Anesthesia
Contrast Media
Fluorescence
X-Rays

Keywords

  • Blood supply
  • Contrast media
  • Experimental studies
  • Function
  • Kidney
  • Radionuclide studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Mariani, G., Augeri, C., Pretolesi, F., Mereto, E., Curti, G., Martinoli, C., ... Derchi, L. E. (2000). Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits. Academic Radiology, 7(9), 705-710.

Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits. / Mariani, Giuliano; Augeri, Carla; Pretolesi, Fabio; Mereto, Eugenio; Curti, Giovanna; Martinoli, Carlo; Martelli, Antonietta; Derchi, Lorenzo E.

In: Academic Radiology, Vol. 7, No. 9, 2000, p. 705-710.

Research output: Contribution to journalArticle

Mariani, G, Augeri, C, Pretolesi, F, Mereto, E, Curti, G, Martinoli, C, Martelli, A & Derchi, LE 2000, 'Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits', Academic Radiology, vol. 7, no. 9, pp. 705-710.
Mariani G, Augeri C, Pretolesi F, Mereto E, Curti G, Martinoli C et al. Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits. Academic Radiology. 2000;7(9):705-710.
Mariani, Giuliano ; Augeri, Carla ; Pretolesi, Fabio ; Mereto, Eugenio ; Curti, Giovanna ; Martinoli, Carlo ; Martelli, Antonietta ; Derchi, Lorenzo E. / Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits. In: Academic Radiology. 2000 ; Vol. 7, No. 9. pp. 705-710.
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abstract = "Rationale and Objectives. Radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. A new method has recently been developed for measuring levels of stable iodine (iodine-127) in biologic samples, based on the detection of x-ray fluorescence photons. In this study, the authors assessed the potential of the new system to evaluate ERPF by using an iodinated contrast medium with adequate glomerular filtration and tubular secretion properties. Materials and Methods. A commercial system was used to evaluate ERPF after intravenous injection of stable I-127 ortho-iodohippurate. The results were compared with the clearance values of I-123 ortho-iodohippurate, considered the reference standard. Seven rabbits under general anesthesia were given intravenous injections of I-123 ortho-iodohippurate and I-127 ortho-iodohippurate. The corresponding plasma curves were evaluated from 4 to 60 minutes to calculate ERPF as the dose/integral of plasma curve. Results. The initial distribution volumes of I-123 ortho-iodohippurate (149.4 mL/kg ± 12.1) and I-127 ortho-iodohippurate (148.8 mL/kg ± 11.8) were virtually superimposable, thus confirming the chemical identity of the two compounds. The plasma clearance values for I-127 ortho-iodohippurate (11.15 mL/min kg-1 ± 1.44) were slightly (not significantly) higher than those for I-123 ortho-iodohippurate (10.49 mL/min kg-1 ± 1.41), perhaps because of a relative 'mass' load effect of the iodinated medium. Conclusion. The results obtained in this study demonstrate the feasibility of the new system for evaluating ERPF, provided that a compound with adequate glomerular filtration and tubular secretion properties is employed.",
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AU - Mariani, Giuliano

AU - Augeri, Carla

AU - Pretolesi, Fabio

AU - Mereto, Eugenio

AU - Curti, Giovanna

AU - Martinoli, Carlo

AU - Martelli, Antonietta

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N2 - Rationale and Objectives. Radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. A new method has recently been developed for measuring levels of stable iodine (iodine-127) in biologic samples, based on the detection of x-ray fluorescence photons. In this study, the authors assessed the potential of the new system to evaluate ERPF by using an iodinated contrast medium with adequate glomerular filtration and tubular secretion properties. Materials and Methods. A commercial system was used to evaluate ERPF after intravenous injection of stable I-127 ortho-iodohippurate. The results were compared with the clearance values of I-123 ortho-iodohippurate, considered the reference standard. Seven rabbits under general anesthesia were given intravenous injections of I-123 ortho-iodohippurate and I-127 ortho-iodohippurate. The corresponding plasma curves were evaluated from 4 to 60 minutes to calculate ERPF as the dose/integral of plasma curve. Results. The initial distribution volumes of I-123 ortho-iodohippurate (149.4 mL/kg ± 12.1) and I-127 ortho-iodohippurate (148.8 mL/kg ± 11.8) were virtually superimposable, thus confirming the chemical identity of the two compounds. The plasma clearance values for I-127 ortho-iodohippurate (11.15 mL/min kg-1 ± 1.44) were slightly (not significantly) higher than those for I-123 ortho-iodohippurate (10.49 mL/min kg-1 ± 1.41), perhaps because of a relative 'mass' load effect of the iodinated medium. Conclusion. The results obtained in this study demonstrate the feasibility of the new system for evaluating ERPF, provided that a compound with adequate glomerular filtration and tubular secretion properties is employed.

AB - Rationale and Objectives. Radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. A new method has recently been developed for measuring levels of stable iodine (iodine-127) in biologic samples, based on the detection of x-ray fluorescence photons. In this study, the authors assessed the potential of the new system to evaluate ERPF by using an iodinated contrast medium with adequate glomerular filtration and tubular secretion properties. Materials and Methods. A commercial system was used to evaluate ERPF after intravenous injection of stable I-127 ortho-iodohippurate. The results were compared with the clearance values of I-123 ortho-iodohippurate, considered the reference standard. Seven rabbits under general anesthesia were given intravenous injections of I-123 ortho-iodohippurate and I-127 ortho-iodohippurate. The corresponding plasma curves were evaluated from 4 to 60 minutes to calculate ERPF as the dose/integral of plasma curve. Results. The initial distribution volumes of I-123 ortho-iodohippurate (149.4 mL/kg ± 12.1) and I-127 ortho-iodohippurate (148.8 mL/kg ± 11.8) were virtually superimposable, thus confirming the chemical identity of the two compounds. The plasma clearance values for I-127 ortho-iodohippurate (11.15 mL/min kg-1 ± 1.44) were slightly (not significantly) higher than those for I-123 ortho-iodohippurate (10.49 mL/min kg-1 ± 1.41), perhaps because of a relative 'mass' load effect of the iodinated medium. Conclusion. The results obtained in this study demonstrate the feasibility of the new system for evaluating ERPF, provided that a compound with adequate glomerular filtration and tubular secretion properties is employed.

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KW - Radionuclide studies

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