Therapeutic drug monitoring (TDM) is an important tool in the management of antiretroviral (ARV) therapy.The gold standard for measuring drugs plasma levels is High-Performance Liquid Chromatographic Assay (HPLC) however it is technically-demanding and time-consuming. We evaluated a new immunoenzymatic test (TDM-ELISA®, Biostrands, Trieste, Italy) for nelfinavir and its active metabolite M8 in comparison with HPLC. A statistically significant difference in Ctrough between the two different tests was demonstrated but this difference was no longer significant when a value of 29% due to M8 aliquot was deleted. This faster TDM-ELISA® may have an important role for TDM in HIV patients taking ARVs.
|Number of pages||3|
|Publication status||Published - Jul 2007|
- Therapeutic drug monitoring
ASJC Scopus subject areas
- Microbiology (medical)