Evaluation of endorphin content in the CSF of patients with trigeminal neuralgia before and after Gasserian ganglion thermocoagulation

G. Salar, S. Mingrino, M. Trabucchi, A. Bosio, C. Semenza

Research output: Contribution to journalArticlepeer-review

Abstract

The β-endorphin content in cerebrospinal fluid (CSF) was evaluated in 10 patients with idiopathic trigeminal neuralgia during medical treatment (with or without carbamazepine) and after selective thermocoagulation of the Gasserian ganglion. These values were compared with those obtained in a control group of seven patients without pain problems. No statistically significant difference was found between patients suffering from trigeminal neuralgia and those without pain. Furthermore, neither pharmacological treatment nor surgery changed CSF endorphin values. It is concluded that there is no pathogenetic relationship between trigeminal neuralgia and endorphins.

Original languageEnglish
Pages (from-to)935-937
Number of pages3
JournalJournal of Neurosurgery
Volume55
Issue number6
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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