Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non- small-cell lung cancer: Amphiregulin and microvessel count are independent prognostic indicators of survival

Gabriella Fontanini, Michelino De Laurentiis, Silvana Vignati, Silvana Chinè, Marco Lucchi, Vanessa Silvestri, Alfredo Mussi, Sabino De Placido, Giampaolo Tortora, A. Raffaele Bianco, William Gullick, Carlo Alberto Angeletti, Generoso Bevilacqua, Fortunato Ciardiello

Research output: Contribution to journalArticle

Abstract

We have determined the expression of transforming growth factor a (TGFα), amphiregulin (AR), CRIPTO, the epidermal growth factor receptor (EGFR), erbB-2, erbB-3, and tumor angiogenesis in a series of 195 patients with stage I-IIIA non-small cell lung cancer (NSCLC) treated with radical surgery to define their usefulness as prognostic indicators of survival. A variable degree of specific staining in cancer cells was observed for the three growth factors and for the three growth factor receptors in the majority of NSCLC patients. A statistically significant association between overexpression of TGFα, AR, and CRIPTO was observed. Enhanced expression of AR was significantly correlated with enhanced expression of erbB-2 and advanced T-stage. A direct association was also detected for overexpression of TGFα and of erbB-2 or erbB-3, respectively. Sex, tumor size, nodal status, stage, microvessel count, as a measure of neovascularization, and AR overexpression significantly correlated with overall survival at univariate analysis. In a Cox multivariate analysis, the only characteristics with an independent prognostic effect on OAS were microvessel count [relative hazard (RH), 6.61; P <0.00001), nodal status (RH, 1.59; P = 0.0013), and AR overexpression (RH, 1.72; P = 0.02). These results suggest that evaluation of neoangiogenesis and of certain growth factors, such as AR, can be useful in addition to conventional pathological staging to select high-risk NSCLC patients who may benefit from post-surgical systemic therapies.

Original languageEnglish
Pages (from-to)241-249
Number of pages9
JournalClinical Cancer Research
Volume4
Issue number1
Publication statusPublished - Jan 1998

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Fontanini, G., De Laurentiis, M., Vignati, S., Chinè, S., Lucchi, M., Silvestri, V., Mussi, A., De Placido, S., Tortora, G., Bianco, A. R., Gullick, W., Angeletti, C. A., Bevilacqua, G., & Ciardiello, F. (1998). Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non- small-cell lung cancer: Amphiregulin and microvessel count are independent prognostic indicators of survival. Clinical Cancer Research, 4(1), 241-249.