Evaluation of fat grafting safety in patients with intra epithelial neoplasia: A matched-cohort study

J. Y. Petit, M. Rietjens, E. Botteri, N. Rotmensz, F. Bertolini, G. Curigliano, P. Rey, C. Garusi, F. De Lorenzi, S. Martella, A. Manconi, B. Barbieri, P. Veronesi, M. Intra, T. Brambullo, A. Gottardi, M. Sommario, G. Lomeo, M. Iera, V. GiovinazzoV. Lohsiriwat

Research output: Contribution to journalArticlepeer-review


Background: Fat grafting is widely carried out in breast cancer patients to improve quality in breast reconstruction. Recently, in vitro and animal studies have questioned the role of adipose tissues in cancer development. Designs: Matched-cohort study. We analysed: (i) 59 intraepithelial neoplasia patients who had undergone lipofilling, with no recurrence between primary surgery and lipofilling. (ii) A control group of 118 matched patients (two controls per lipofilling patient) with the corresponding recurrence-free intervals. Both groups were also matched for main cancer criteria. A local event (LE) was the primary end point, with follow-up starting from the baseline. Results: Median follow-up was 63 and 66 months from surgery, and 38 and 42 from baseline, for the lipofilling and control groups, respectively; the 5-year cumulative incidence of LE was 18% and 3% (P = 0.02). Ki-67 was the significant factor in univariate survival analysis. A subgroup analysis showed that lipofilling increased the risk of LE in women

Original languageEnglish
Pages (from-to)1479-1484
Number of pages6
JournalAnnals of Oncology
Issue number6
Publication statusPublished - Jun 2013


  • Breast cancer
  • Breast reconstruction
  • Ductal carcinoma in situ
  • Fat grafting
  • Intra epithelial neoplasia
  • Lipofilling

ASJC Scopus subject areas

  • Oncology
  • Hematology


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