TY - JOUR
T1 - Evaluation of four radiopharmaceuticals for imaging inflammation in a rabbit model of arthritis
AU - Chinol, Marco
AU - Vallabhajosula, Shankar
AU - Goldsmith, Stanley J.
AU - Paganelli, Giovanni
AU - Palestro, Christopher J.
PY - 1996/9
Y1 - 1996/9
N2 - We compared the utility of four radiopharmaceuticals;111In-chloride,67Ga-citrate,111In labeled leukocytes (WBCs) and99mTc-MDP for assessing the inflammatory response in antigen induced arthritis in a rabbit model. A total of 20 rabbits, divided into four equal groups, were included in this study. Each group was studied twice with a single radiotracer: a baseline study and a follow-up study after induction of the arthritis. Knee to knee, knee to whole body, and knee to liver (except for the group studied with99mTc-MDP) ratios were generated. Knee to knee ratios showed no significant change from baseline to arthritis studies in any of the four groups. Significantly increased knee to total body ratios were seen in all of the groups, except for the group studied with99mTc-MDP. The greatest increase was seen in the group studied with111In-chloride. Significantly increased knee to liver ratios were observed in all three groups for which these ratios were generated and again the greatest increase was observed in the group studied with111In-chloride. In summary, based on the higher uptake observed in this group, of the four radiotracers evaluated,111In-chloride is probably the most useful for monitoring the inflammatory response in antigen induced arthritis. The symmetry of the response suggests that it may also be useful in monitoring the response to therapy.
AB - We compared the utility of four radiopharmaceuticals;111In-chloride,67Ga-citrate,111In labeled leukocytes (WBCs) and99mTc-MDP for assessing the inflammatory response in antigen induced arthritis in a rabbit model. A total of 20 rabbits, divided into four equal groups, were included in this study. Each group was studied twice with a single radiotracer: a baseline study and a follow-up study after induction of the arthritis. Knee to knee, knee to whole body, and knee to liver (except for the group studied with99mTc-MDP) ratios were generated. Knee to knee ratios showed no significant change from baseline to arthritis studies in any of the four groups. Significantly increased knee to total body ratios were seen in all of the groups, except for the group studied with99mTc-MDP. The greatest increase was seen in the group studied with111In-chloride. Significantly increased knee to liver ratios were observed in all three groups for which these ratios were generated and again the greatest increase was observed in the group studied with111In-chloride. In summary, based on the higher uptake observed in this group, of the four radiotracers evaluated,111In-chloride is probably the most useful for monitoring the inflammatory response in antigen induced arthritis. The symmetry of the response suggests that it may also be useful in monitoring the response to therapy.
KW - In-chloride
KW - In-WBCs
KW - Gacitrate
KW - Tc-MDP
KW - antigen induced arthritis in rabbits
KW - imaging joint inflammation
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U2 - 10.1007/BF03164734
DO - 10.1007/BF03164734
M3 - Article
C2 - 8883703
AN - SCOPUS:0029842054
VL - 10
SP - 287
EP - 291
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
SN - 0914-7187
IS - 3
ER -