Abstract
Sixty 99Mo/99mTc wet column generators, loaded with two different 99Mo activities, were analyzed in order to assess the quality of their eluates. Each elution was used for labeling of different radiopharmaceuticals, in order to evaluate whether "risky" elutions, namely those performed just after generator delivery and at 72 hours or more from the last elution, could be conveniently employed when fresh available radioactivity is not enough for the planned labeling or when shipping problems arise, or delay in delivery of a new generator occurs. Radiochemical quality control of all radiopharmaceuticals labeled with these elutions was performed. The elutions differed mainly in 99Tc ground state (99gTc) and amounts of oxidizing impurities. Radiolabeling procedures, however, were not affected, suggesting that these "risky" elutions might be appropriately used, in "emergency" conditions, for labeling radiopharmaceuticals although their radiochemical purity control is recommended prior to patient administration.
| Original language | English |
|---|---|
| Pages (from-to) | 7-10 |
| Number of pages | 4 |
| Journal | Journal of Radioanalytical and Nuclear Chemistry |
| Volume | 265 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jun 2005 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Inorganic Chemistry
- Nuclear Energy and Engineering
Cite this
Evaluation of fresh and old eluate of 99Mo/99mTc generators used for labeling of different pharmaceutical kits. / Urbano, N.; Modoni, S.; Guerra, M.; Chinol, M.
In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 265, No. 1, 06.2005, p. 7-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of fresh and old eluate of 99Mo/99mTc generators used for labeling of different pharmaceutical kits
AU - Urbano, N.
AU - Modoni, S.
AU - Guerra, M.
AU - Chinol, M.
PY - 2005/6
Y1 - 2005/6
N2 - Sixty 99Mo/99mTc wet column generators, loaded with two different 99Mo activities, were analyzed in order to assess the quality of their eluates. Each elution was used for labeling of different radiopharmaceuticals, in order to evaluate whether "risky" elutions, namely those performed just after generator delivery and at 72 hours or more from the last elution, could be conveniently employed when fresh available radioactivity is not enough for the planned labeling or when shipping problems arise, or delay in delivery of a new generator occurs. Radiochemical quality control of all radiopharmaceuticals labeled with these elutions was performed. The elutions differed mainly in 99Tc ground state (99gTc) and amounts of oxidizing impurities. Radiolabeling procedures, however, were not affected, suggesting that these "risky" elutions might be appropriately used, in "emergency" conditions, for labeling radiopharmaceuticals although their radiochemical purity control is recommended prior to patient administration.
AB - Sixty 99Mo/99mTc wet column generators, loaded with two different 99Mo activities, were analyzed in order to assess the quality of their eluates. Each elution was used for labeling of different radiopharmaceuticals, in order to evaluate whether "risky" elutions, namely those performed just after generator delivery and at 72 hours or more from the last elution, could be conveniently employed when fresh available radioactivity is not enough for the planned labeling or when shipping problems arise, or delay in delivery of a new generator occurs. Radiochemical quality control of all radiopharmaceuticals labeled with these elutions was performed. The elutions differed mainly in 99Tc ground state (99gTc) and amounts of oxidizing impurities. Radiolabeling procedures, however, were not affected, suggesting that these "risky" elutions might be appropriately used, in "emergency" conditions, for labeling radiopharmaceuticals although their radiochemical purity control is recommended prior to patient administration.
UR - http://www.scopus.com/inward/record.url?scp=24644501256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24644501256&partnerID=8YFLogxK
U2 - 10.1007/s10967-005-0782-x
DO - 10.1007/s10967-005-0782-x
M3 - Article
AN - SCOPUS:24644501256
VL - 265
SP - 7
EP - 10
JO - Journal of Radioanalytical Chemistry
JF - Journal of Radioanalytical Chemistry
SN - 0022-4081
IS - 1
ER -