Evaluation of function and structure of arterial wall in girls and young women with Turner syndrome

G. Radetti, L. Mazzanti, C. Di Somma, M. Salerno, E. Gottardi, D. Capalbo, F. Tamburrino, A. Colao

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Abstract

Purpose: Patients with Turner syndrome (TS) are frequently affected by congenital as well as acquired cardiovascular diseases. The aim of the study was to evaluate the blood pressure, the endothelial function (FMD) and the intima media thickness (IMT) at the level of the common carotid arteries in a group of girls and young women with TS in comparison to healthy controls. Methods: We evaluated 40 unselected TS patients, with a mean age of 18.6 ± 0.9 years and 103 age matched healthy subjects. Main outcome measures: blood pressure, FMD and IMT. Results: No differences were found in systolic and diastolic blood pressure between TS patients and controls. FMD was higher in TS than in controls (14.2 ± 1.4 vs 11.4 ± 0.3 %, p = 0.005) whereas IMT was not statistically different in the two study groups (0.54 ± 0.04 vs 0.57 ± 0.01 mm). However, in TS patients an inverse correlation was found between FMD and both age (-0.03 ± 0.01, p = 0.003) and years of estrogen therapy (-0.72 ± 0.31, p <0.03), whereas a positive correlation was found between IMT and age (R 2 = 0.35, p <0.0001) and estrogen therapy duration (R 2 = 0.65, p <0.0001), suggesting a clear tendency toward a premature decrease in FMD and premature increase in IMT compared to controls. Conclusions: Young TS patients show an arterial wall which is functionally and structurally comparable or betterthan controls. They show, however, a premature derangement of the arterial function and structure, which seems to be partly influenced by age and duration of oestrogen treatment.

Original languageEnglish
Pages (from-to)963-970
Number of pages8
JournalJournal of Endocrinological Investigation
Volume38
Issue number9
DOIs
Publication statusPublished - Sep 26 2015

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Keywords

  • Blood pressure
  • Endothelial function
  • Intima media thickness
  • Turner syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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