Evaluation of high sensitive troponin in erectile dysfunction

Alessandra Barassi, Raffaele Pezzilli, Antonio Maria Morselli-Labate, Elena Dozio, Luca Massaccesi, Francesca Ghilardi, Clara Anna Linda Damele, Giovanni Maria Colpi, Gian Vico Melzi D'Eril, Massimiliano Marco Corsi Romanelli

Research output: Contribution to journalArticle

Abstract

Background. Evidence is accumulating in favour of a link between erectile dysfunction (ED) and coronary artery diseases. We investigated the presence of cardiac injury in patients who have had arteriogenic and nonarteriogenic ED using the hs-Tn levels. Methods. The diagnosis of ED was based on the International Index of Erectile Function 5-questionnaire (IIF-5) and patients were classified as arteriogenic (A-ED, n = 40), nonarteriogenic (NA-ED, n = 48), and borderline (BL-ED, n = 32) patients in relation to the results of echo-color-Doppler examination of cavernous arteries. The level of hs-TnT and hs-TnI was measured in 120 men with a history of ED of less than one year with no clinical evidence of cardiac ischemic disease. Results. The levels of both hs-TnT and hs-TnI were within the reference range and there was no significant (P > 0.05) difference between patients of the three groups. The hs-CRP values were higher in A-ED men compared with NA-ED (P = 0.048) but not compared with BL-ED (P = 0.136) and negatively correlated with IIF-5 (r =-0.480; P = 0.031). Conclusions. In ED patients of the three groups the measurement of hs-Tn allows us to exclude the presence of cardiac involvement at least when the history of ED is less than one year and the men are without atherosclerotic risk factors.

Original languageEnglish
Article number548951
JournalDisease Markers
Volume2015
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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    Barassi, A., Pezzilli, R., Morselli-Labate, A. M., Dozio, E., Massaccesi, L., Ghilardi, F., Damele, C. A. L., Colpi, G. M., Melzi D'Eril, G. V., & Corsi Romanelli, M. M. (2015). Evaluation of high sensitive troponin in erectile dysfunction. Disease Markers, 2015, [548951]. https://doi.org/10.1155/2015/548951