Evaluation of histological and ultrastructural aspects of endometrium during treatment with gestrinone in women with amenorrhea or spotting

L. Fedele, M. Marchini, A. Baglioni, G. Dell'Antonio, T. Motta

Research output: Contribution to journalArticlepeer-review

Abstract

Nineteen patients with a laparoscopic diagnosis of endometriosis were treated with gestrinone at a dosage of 2.5 mg twice a week for 6 months. In 7 who reported spotting in the first 3 months, the dose was increased to 2.5 mg three times a week during the second trimester. An endometrial sample was obtained from each patient at the time of laparoscopy (basal) and at 3 and 6 months of treatment. Endometrial structure and ultrastructure were studied. Areas of hemorrhage and of loss of surface epithelium and a lesser degree of involution of the surface epithelium were observed in the 3-month samples of 7 patients with spotting, compared with 12 amenorrhea. It is hypothesized that incomplete endometrial involution could be due to differences in gestrinone pharmacokinetics in individual patients, in the quality and/or quantity of endometrial cytosolic receptors for sex steroids, or in endocrine compensation to administration of the drug.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalActa Obstetricia et Gynecologica Scandinavica
Volume69
Issue number2
Publication statusPublished - 1990

Keywords

  • endometriosis
  • endometrium
  • gestrinone
  • ultrastructure

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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