Evaluation of image reconstruction algorithms encompassing Time-Of-Flight and Point Spread Function modelling for quantitative cardiac PET: Phantom studies

L. Presotto, L. Gianolli, M. C. Gilardi, V. Bettinardi

Research output: Contribution to journalArticle


Background: To perform kinetic modelling quantification, PET dynamic data must be acquired in short frames, where different critical conditions are met. The accuracy of reconstructed images influences quantification. The added value of Time-Of-Flight (TOF) and Point Spread Function (PSF) in cardiac image reconstruction was assessed.

Methods: A static phantom was used to simulate two extreme conditions: (i) the bolus passage and (ii) the steady uptake. Various count statistics and independent noise realisations were considered. A moving phantom filled with two different radionuclides was used to simulate: (i) a great range of contrasts and (ii) the cardio/respiratory motion. Analytical and iterative reconstruction (IR) algorithms also encompassing TOF and PSF modelling were evaluated.

Results: Both analytic and IR algorithms provided good results in all the evaluated conditions. The amount of bias introduced by IR was found to be limited. TOF allowed faster convergence and lower noise levels. PSF achieved near full myocardial activity recovery in static conditions. Motion degraded performances, but the addition of both TOF and PSF maintained the best overall behaviour.

Conclusions: IR accounting for TOF and PSF can be recommended for the quantification of dynamic cardiac PET studies as they improve the results compared to analytic and standard IR.

Original languageEnglish
Pages (from-to)351-363
Number of pages13
JournalJournal of Nuclear Cardiology
Issue number2
Publication statusPublished - 2015



  • image processing
  • image reconstruction
  • myocardial perfusion imaging: PET
  • Partial volume effect

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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