Evaluation of in vitro antimicrobial activity of lomefloxacin against staphylococci, enterococci, Enterobacteriaceae, and Pseudomonas aeruginosa

Gian Maria Rossolini, Silvia Valentini, Giuseppe Satta

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro antimicrobial activity of lomefloxacin and other antibiotics (norfloxacin, β-lactams, cotrimoxazole, netilmicin, and miokamycin) was evaluated against 317 clinical isolates including Staphylococcus aureus, enterococci, Enterobacteriaceae, and Pseudomonas aeruginosa. Lomefloxacin showed a high in vitro activity against a wide variety of bacterial species. Against Enterobacteriaceae, lomefloxacin displayed the highest activity (MIC90s, ≤1 μg/ml), and it was usually more active than ampicillin and netilmicin, and often more active than cotrimoxazole. Lomefloxacin showed a good antimicrobial activity also against both methicillin-susceptible and methicillin-resistant S. aureus, as it was able to inhibit 90% of staphylococcal strains at a concentration ≤2 μg/ml. Against enterococci and P. aeruginosa, lomefloxacin was usually less active (MIC90s, 8 μg/ml). As compared to norfloxacin, lomefloxacin displayed an overall similar activity against staphylococci and enterococci, but appeared less active against Gram-negative bacteria. Bactericidal activity of lomefloxacin against E. coli, when assayed by a novel method, proved to be high, and results indicate that an oral dose of 200 mg of lomefloxacin should exert a very high bactericidal activity against E. coli in urinary tract infections, even in those sustained by large bacterial populations.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalDiagnostic Microbiology and Infectious Disease
Volume12
Issue number3 SUPPL. 1
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Evaluation of in vitro antimicrobial activity of lomefloxacin against staphylococci, enterococci, Enterobacteriaceae, and Pseudomonas aeruginosa'. Together they form a unique fingerprint.

Cite this