Abstract
In vitro antimicrobial activity of lomefloxacin and other antibiotics (norfloxacin, β-lactams, cotrimoxazole, netilmicin, and miokamycin) was evaluated against 317 clinical isolates including Staphylococcus aureus, enterococci, Enterobacteriaceae, and Pseudomonas aeruginosa. Lomefloxacin showed a high in vitro activity against a wide variety of bacterial species. Against Enterobacteriaceae, lomefloxacin displayed the highest activity (MIC90s, ≤1 μg/ml), and it was usually more active than ampicillin and netilmicin, and often more active than cotrimoxazole. Lomefloxacin showed a good antimicrobial activity also against both methicillin-susceptible and methicillin-resistant S. aureus, as it was able to inhibit 90% of staphylococcal strains at a concentration ≤2 μg/ml. Against enterococci and P. aeruginosa, lomefloxacin was usually less active (MIC90s, 8 μg/ml). As compared to norfloxacin, lomefloxacin displayed an overall similar activity against staphylococci and enterococci, but appeared less active against Gram-negative bacteria. Bactericidal activity of lomefloxacin against E. coli, when assayed by a novel method, proved to be high, and results indicate that an oral dose of 200 mg of lomefloxacin should exert a very high bactericidal activity against E. coli in urinary tract infections, even in those sustained by large bacterial populations.
Original language | English |
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Pages (from-to) | 57-64 |
Number of pages | 8 |
Journal | Diagnostic Microbiology and Infectious Disease |
Volume | 12 |
Issue number | 3 SUPPL. 1 |
DOIs | |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Immunology
- Microbiology
- Parasitology
- Virology
- Immunology and Allergy
- Infectious Diseases