Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment

Alessandra Frezzolini, Ornella De Pità, Nicoletta Cassano, Vito D'Argento, Giulio Ferranti, Raffaele Filotico, Gino A. Vena

Research output: Contribution to journalArticle

Abstract

Background: Physical urticaria (PU) includes a heterogeneous group of urticarias whose etiopathogenic aspects are still obscure and whose therapeutical management is often difficult. We have previously demonstrated the efficacy of a sequential treatment with nimesulide, a unique nonsteroidal anti-inflammatory drug, and ketotifen in various forms of PU. Methods: The expression of some inflammatory parameters was evaluated in 10 patients affected with some forms of PU. In particular, serum levels of interleukin (IL)-4, IL-1β, tumor necrosis factor (TNF)-α, adhesion molecules (sELAM, sICAM-1 and sVCAM), soluble receptors (sIL-2R, sCD30, sCD23) and IgE were assessed. Moreover, the cutaneous expression of IL-1β, TNF-α and ICAM-1 was studied on biopsy specimens taken from nonlesional skin of patients. The same parameters were further evaluated in both skin and serum following treatment with nimesulide and ketotifen, in order to better understand the possible effects of these agents on the inflammatory network of PU. Results: Before therapy we could detect significantly higher serum levels of IL-1β and TNF-α (P <0.001) and of circulating adhesion molecules in comparison with controls (sELAM, sICAM: P <0.001; sVCAM: P <0.02); after treatment, a significant reduction of each was observed (P <0.05). Simultaneously, a high expression of IL-1β, TNF-α and ICAM-1 was detected in all skin specimens at the baseline, with a relevant decrease following therapy. Conclusions: These results confirm the therapeutical value of treatment with nimesulide and ketotifen in PU and suggest that these agents are able to reduce the release and the expression of some inflammatory molecules that are up-regulated in PU.

Original languageEnglish
Pages (from-to)431-438
Number of pages8
JournalInternational Journal of Dermatology
Volume41
Issue number7
DOIs
Publication statusPublished - 2002

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Anti-Allergic Agents
Urticaria
nimesulide
Anti-Inflammatory Agents
Ketotifen
Interleukin-1
Tumor Necrosis Factor-alpha
Skin
Intercellular Adhesion Molecule-1
Therapeutics
Serum
Interleukin-4
Immunoglobulin E
Biopsy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Dermatology

Cite this

Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment. / Frezzolini, Alessandra; De Pità, Ornella; Cassano, Nicoletta; D'Argento, Vito; Ferranti, Giulio; Filotico, Raffaele; Vena, Gino A.

In: International Journal of Dermatology, Vol. 41, No. 7, 2002, p. 431-438.

Research output: Contribution to journalArticle

Frezzolini, Alessandra ; De Pità, Ornella ; Cassano, Nicoletta ; D'Argento, Vito ; Ferranti, Giulio ; Filotico, Raffaele ; Vena, Gino A. / Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment. In: International Journal of Dermatology. 2002 ; Vol. 41, No. 7. pp. 431-438.
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AU - Frezzolini, Alessandra

AU - De Pità, Ornella

AU - Cassano, Nicoletta

AU - D'Argento, Vito

AU - Ferranti, Giulio

AU - Filotico, Raffaele

AU - Vena, Gino A.

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