Abstract
Objective: To investigate the correlation among carotid plaque contrast enhancement (CPCE) at MRI, inflammatory cell infiltration (ICI) at histopathology, and carotid stenosis degree. Materials and methods: Twenty-eight patients (19 males; mean age 67 ± 9 years) scheduled for thromboendarterectomy prospectively underwent 1.5-T MR imaging using: (a) axial T1-weighted gradient-echo (T1wGRE) sequence centered on carotid bifurcations; (b) contrast-enhanced MR angiography (CE-MRA) with 0.1 mmol/kg of gadobenate dimeglumine; (c) enhanced axial T1wGRE sequence as in (a), 3 min after contrast injection. A three-point score system (absent, focal, wide) was used to assess CPCE on native and subtracted MRI images (c minus a) and ICI at histopathology. Carotid stenosis degree was determined on CE-MRA. Results: Six CPCE studies were discarded due to patient movement. In the remaining 22 studies, CPCE was absent, focal and wide in 13, 6 and 3 cases, respectively; ICI was absent, focal and wide in 13, 7 and 2 cases, respectively (k = 0.57). On CE-MRA 21/28 stenoses were severe and 7/28 moderate. There was no correlation either with ICI (p = 1.000, n = 28) or CPCE (p = 0.747, n = 22). Conclusion: The correlation between CPCE and ICI suggests a role for CPCE as an independent marker of plaque inflammation.
| Original language | English |
|---|---|
| Journal | European Journal of Radiology |
| Volume | 80 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 2011 |
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Keywords
- Atherosclerosis
- Carotid stenosis
- Contrast material
- Magnetic resonance angiography
- Magnetic resonance imaging
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Evaluation of inflammatory status of atherosclerotic carotid plaque before thromboendarterectomy using delayed contrast-enhanced subtracted images after magnetic resonance angiography. / Papini, Giacomo D E; Di Leo, Giovanni; Tritella, Stefania; Nano, Giovanni; Cotticelli, Biagio; Clemente, Claudio; Tealdi, Domenico G.; Sardanelli, Francesco.
In: European Journal of Radiology, Vol. 80, No. 3, 12.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of inflammatory status of atherosclerotic carotid plaque before thromboendarterectomy using delayed contrast-enhanced subtracted images after magnetic resonance angiography
AU - Papini, Giacomo D E
AU - Di Leo, Giovanni
AU - Tritella, Stefania
AU - Nano, Giovanni
AU - Cotticelli, Biagio
AU - Clemente, Claudio
AU - Tealdi, Domenico G.
AU - Sardanelli, Francesco
PY - 2011/12
Y1 - 2011/12
N2 - Objective: To investigate the correlation among carotid plaque contrast enhancement (CPCE) at MRI, inflammatory cell infiltration (ICI) at histopathology, and carotid stenosis degree. Materials and methods: Twenty-eight patients (19 males; mean age 67 ± 9 years) scheduled for thromboendarterectomy prospectively underwent 1.5-T MR imaging using: (a) axial T1-weighted gradient-echo (T1wGRE) sequence centered on carotid bifurcations; (b) contrast-enhanced MR angiography (CE-MRA) with 0.1 mmol/kg of gadobenate dimeglumine; (c) enhanced axial T1wGRE sequence as in (a), 3 min after contrast injection. A three-point score system (absent, focal, wide) was used to assess CPCE on native and subtracted MRI images (c minus a) and ICI at histopathology. Carotid stenosis degree was determined on CE-MRA. Results: Six CPCE studies were discarded due to patient movement. In the remaining 22 studies, CPCE was absent, focal and wide in 13, 6 and 3 cases, respectively; ICI was absent, focal and wide in 13, 7 and 2 cases, respectively (k = 0.57). On CE-MRA 21/28 stenoses were severe and 7/28 moderate. There was no correlation either with ICI (p = 1.000, n = 28) or CPCE (p = 0.747, n = 22). Conclusion: The correlation between CPCE and ICI suggests a role for CPCE as an independent marker of plaque inflammation.
AB - Objective: To investigate the correlation among carotid plaque contrast enhancement (CPCE) at MRI, inflammatory cell infiltration (ICI) at histopathology, and carotid stenosis degree. Materials and methods: Twenty-eight patients (19 males; mean age 67 ± 9 years) scheduled for thromboendarterectomy prospectively underwent 1.5-T MR imaging using: (a) axial T1-weighted gradient-echo (T1wGRE) sequence centered on carotid bifurcations; (b) contrast-enhanced MR angiography (CE-MRA) with 0.1 mmol/kg of gadobenate dimeglumine; (c) enhanced axial T1wGRE sequence as in (a), 3 min after contrast injection. A three-point score system (absent, focal, wide) was used to assess CPCE on native and subtracted MRI images (c minus a) and ICI at histopathology. Carotid stenosis degree was determined on CE-MRA. Results: Six CPCE studies were discarded due to patient movement. In the remaining 22 studies, CPCE was absent, focal and wide in 13, 6 and 3 cases, respectively; ICI was absent, focal and wide in 13, 7 and 2 cases, respectively (k = 0.57). On CE-MRA 21/28 stenoses were severe and 7/28 moderate. There was no correlation either with ICI (p = 1.000, n = 28) or CPCE (p = 0.747, n = 22). Conclusion: The correlation between CPCE and ICI suggests a role for CPCE as an independent marker of plaque inflammation.
KW - Atherosclerosis
KW - Carotid stenosis
KW - Contrast material
KW - Magnetic resonance angiography
KW - Magnetic resonance imaging
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UR - http://www.scopus.com/inward/citedby.url?scp=80053651997&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2011.01.029
DO - 10.1016/j.ejrad.2011.01.029
M3 - Article
C2 - 21310564
AN - SCOPUS:80053651997
VL - 80
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 3
ER -