Evaluation of influenza vaccination efficacy in reducing influenza-related complications and excess mortality in Northern Italy (2014-2017)

Giuseppe Marano, Patrizia Boracchi, Ester Luconi, Elena Pariani, Laura Pellegrinelli, Cristina Galli, Cecilia E. Gandolfi, Michele Magoni, Antonio Piro, Carmelo Scarcella, Silvana Castaldi, Elia M. Biganzoli

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The main objective of this study was to estimate the efficacy of influenza vaccination in reducing influenza-attributable hospitalization and emergency room (ER) admission for severe complications and influenza-attributable excess mortality in individuals ≥65 years of age. Methods: We analyzed the ≥65 years-old community (n = 952,822) afferent to the Brescia (Northern Italy) Health Protection Agency, considered an Italian population reference, to evaluate the efficacy of influenza vaccination (seasons 2014–17) in reducing deaths, ER-admissions, and hospitalizations for influenza-related complications in the elderly. Results: A protective effect of influenza vaccination emerged in reducing hospitalization and ER admission for diseases of the respiratory system and for death from all causes in people ≥65 years. The major effect of influenza vaccination was the reduction in risk of death from all causes, increasing with age and comorbidity. Conclusion: Influenza vaccination has reduced the number of ER admissions and hospitalizations caused by influenza-related complications and has prevented death among high-risk groups in elderly ≥65 years, resulting in social and public health cost savings. Stronger or new vaccination strategies are needed to improve vaccination rates among the elderly.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
JournalExpert Review of Vaccines
Volume20
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • cardiac disease and stroke
  • death from all causes
  • diseases of the respiratory system
  • Efficacy of influenza vaccination
  • elderly

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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