TY - JOUR
T1 - Evaluation of intraoperative slow-release dexamethasone implant combined with idiopathic epiretinal membrane removal
AU - Savastano, Alfonso
AU - Bitossi, Alice
AU - Giansanti, Fabrizio
AU - Vannozzi, Lorenzo
AU - Caporossi, Tomaso
AU - Barca, Francesco
AU - Virgili, Gianni
AU - Gambini, Gloria
AU - De Vico, Umberto
AU - Bernardinelli, Patrizio
AU - Savastano, Maria Cristina
AU - Rizzo, Stanislao
N1 - Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Purpose: To evaluate the efficacy of intraoperative slow-release dexamethasone implant (DEX) combined with removal of idiopathic epiretinal membrane (ERM). Methods: In this observational retrospective study, data of 40 patients with phakic eyes affected by idiopathic ERM were analysed. All patients underwent cataract phacoemulsification, 25-gauge (G) pars plana vitrectomy (PPV), ERM removal with DEX implant (“DEX YES” group, #20) or without DEX implant (“DEX NO” group, #20). We collected data on best-corrected visual acuity (BCVA) < 20/40 Snellen charts, central macular thickness (CMT) ≤ 400 μm (measured by SD-OCT) and integrity of sub-foveal ellipsoid/myoid zone. BCVA, CMT and intraocular pressure (IOP) were evaluated at baseline as well as 15, 30 and 90 days after surgery. Results: In the “DEX YES” group, statistically significant BCVA improvement was observed at 15, 30 and 90 days (p < 0.001), while in the “DEX NO” group, improvements were observed only at 30 and 90 days (p < 0.001). In both groups, CMT significantly decreased at each follow-up visit (p < 0.001), and no statistically significant increase of IOP was detected at each follow-up visit. Conclusions: In this study, DEX accelerated the improvement of BCVA at 15 days after surgery. However, no evidence of further anatomical (CMT) and functional (BCVA) DEX effectiveness combined with removal of idiopathic ERM by 25-G PPV at 30 and 90 days follow-up was observed.[Figure not available: see fulltext.]
AB - Purpose: To evaluate the efficacy of intraoperative slow-release dexamethasone implant (DEX) combined with removal of idiopathic epiretinal membrane (ERM). Methods: In this observational retrospective study, data of 40 patients with phakic eyes affected by idiopathic ERM were analysed. All patients underwent cataract phacoemulsification, 25-gauge (G) pars plana vitrectomy (PPV), ERM removal with DEX implant (“DEX YES” group, #20) or without DEX implant (“DEX NO” group, #20). We collected data on best-corrected visual acuity (BCVA) < 20/40 Snellen charts, central macular thickness (CMT) ≤ 400 μm (measured by SD-OCT) and integrity of sub-foveal ellipsoid/myoid zone. BCVA, CMT and intraocular pressure (IOP) were evaluated at baseline as well as 15, 30 and 90 days after surgery. Results: In the “DEX YES” group, statistically significant BCVA improvement was observed at 15, 30 and 90 days (p < 0.001), while in the “DEX NO” group, improvements were observed only at 30 and 90 days (p < 0.001). In both groups, CMT significantly decreased at each follow-up visit (p < 0.001), and no statistically significant increase of IOP was detected at each follow-up visit. Conclusions: In this study, DEX accelerated the improvement of BCVA at 15 days after surgery. However, no evidence of further anatomical (CMT) and functional (BCVA) DEX effectiveness combined with removal of idiopathic ERM by 25-G PPV at 30 and 90 days follow-up was observed.[Figure not available: see fulltext.]
KW - Epiretinal membrane
KW - Innovative biotechnology
KW - Intravitreal dexamethasone
KW - Macular pucker
KW - Personalized medicine
KW - Vitrectomy
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U2 - 10.1007/s00417-020-04911-5
DO - 10.1007/s00417-020-04911-5
M3 - Article
C2 - 32892264
AN - SCOPUS:85090313144
VL - 259
SP - 379
EP - 385
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
SN - 0721-832X
IS - 2
ER -