Evaluation of LRRK2 G2019S penetrance: Relevance for genetic counseling in Parkinson disease

S. Goldwurm, M. Zini, L. Mariani, S. Tesei, R. Miceli, F. Sironi, M. Clementi, V. Bonifati, G. Pezzoli

Research output: Contribution to journalArticle

Abstract

We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.

Original languageEnglish
Pages (from-to)1141-1143
Number of pages3
JournalNeurology
Volume68
Issue number14
DOIs
Publication statusPublished - Apr 2007

ASJC Scopus subject areas

  • Neuroscience(all)

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    Goldwurm, S., Zini, M., Mariani, L., Tesei, S., Miceli, R., Sironi, F., Clementi, M., Bonifati, V., & Pezzoli, G. (2007). Evaluation of LRRK2 G2019S penetrance: Relevance for genetic counseling in Parkinson disease. Neurology, 68(14), 1141-1143. https://doi.org/10.1212/01.wnl.0000254483.19854.ef