Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing's syndrome and in patients with adrenal incidentaloma

Alessandro Sartorio, Antonio Conti, Simona Ferrero, Salvatore Giambona, Tiziana Re, Elena Passini, Bruno Ambrosi

Research output: Contribution to journalArticlepeer-review

Abstract

Although steroid-induced negative effects on bone and collagen have been well described in corticosteroid-treated patients, few studies have extensively evaluated bone and collagen turnover in patients with endogenous Cushing's syndrome. In this work serum bone-Gla protein (BGP), C-terminal cross-linked telopeptide of type I collagen (ICTP) and N-terminal propeptide of type III procollagen (PIIINP) levels were determined in patients with active (n = 12) and preclinical (n = 6) Cushing's syndrome, adrenal incidentalomas (n = 35) and in healthy controls (n = 28). In patients with overt Cushing's syndrome, serum BGP (0.9 ± 0.2 ng/ml), ICTP (2.7 ± 0.2 ng/ml) and PIIINP (1.9 ± 0.2 ng/ml) levels were significantly lower (P <0.0001) than in controls (5.5 ± 0.2, 3.9 ± 0.2 and 3.2 ± 0.2 ng/ml respectively). In preclinical Cushing's syndrome, serum BGP (2.5 ± 0.8 ng/ml), ICTP (2.2 ±).1 ng/ml) and PIIINP (2.2 ± 0.2 ng/ml) levels were significantly lower than in normal subjects (P <0.0001, P <0.0001 and P <0.02 respectively), being similar to those recorded in over Cushing's syndrome. In patients with adrenal incidentaloma, serum BGP (4.2 ± 0.5 ng/ml) and ICTP (2.9 ± 0.2 ng/ml) levels were significantly lower than those found in controls (P <0.05 and P <0.001 respectively), while serum PIIINP levels (3.6 ± 0.2 ng/ml) did not differ from those of normals. In particular, 9/35 patients with adrenal incidentaloma had markedly depressed BGP levels (

Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalEuropean Journal of Endocrinology
Volume138
Issue number2
DOIs
Publication statusPublished - Feb 1998

ASJC Scopus subject areas

  • Endocrinology

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