TY - JOUR
T1 - Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing's syndrome and in patients with adrenal incidentaloma
AU - Sartorio, Alessandro
AU - Conti, Antonio
AU - Ferrero, Simona
AU - Giambona, Salvatore
AU - Re, Tiziana
AU - Passini, Elena
AU - Ambrosi, Bruno
PY - 1998/2
Y1 - 1998/2
N2 - Although steroid-induced negative effects on bone and collagen have been well described in corticosteroid-treated patients, few studies have extensively evaluated bone and collagen turnover in patients with endogenous Cushing's syndrome. In this work serum bone-Gla protein (BGP), C-terminal cross-linked telopeptide of type I collagen (ICTP) and N-terminal propeptide of type III procollagen (PIIINP) levels were determined in patients with active (n = 12) and preclinical (n = 6) Cushing's syndrome, adrenal incidentalomas (n = 35) and in healthy controls (n = 28). In patients with overt Cushing's syndrome, serum BGP (0.9 ± 0.2 ng/ml), ICTP (2.7 ± 0.2 ng/ml) and PIIINP (1.9 ± 0.2 ng/ml) levels were significantly lower (P <0.0001) than in controls (5.5 ± 0.2, 3.9 ± 0.2 and 3.2 ± 0.2 ng/ml respectively). In preclinical Cushing's syndrome, serum BGP (2.5 ± 0.8 ng/ml), ICTP (2.2 ±).1 ng/ml) and PIIINP (2.2 ± 0.2 ng/ml) levels were significantly lower than in normal subjects (P <0.0001, P <0.0001 and P <0.02 respectively), being similar to those recorded in over Cushing's syndrome. In patients with adrenal incidentaloma, serum BGP (4.2 ± 0.5 ng/ml) and ICTP (2.9 ± 0.2 ng/ml) levels were significantly lower than those found in controls (P <0.05 and P <0.001 respectively), while serum PIIINP levels (3.6 ± 0.2 ng/ml) did not differ from those of normals. In particular, 9/35 patients with adrenal incidentaloma had markedly depressed BGP levels (
AB - Although steroid-induced negative effects on bone and collagen have been well described in corticosteroid-treated patients, few studies have extensively evaluated bone and collagen turnover in patients with endogenous Cushing's syndrome. In this work serum bone-Gla protein (BGP), C-terminal cross-linked telopeptide of type I collagen (ICTP) and N-terminal propeptide of type III procollagen (PIIINP) levels were determined in patients with active (n = 12) and preclinical (n = 6) Cushing's syndrome, adrenal incidentalomas (n = 35) and in healthy controls (n = 28). In patients with overt Cushing's syndrome, serum BGP (0.9 ± 0.2 ng/ml), ICTP (2.7 ± 0.2 ng/ml) and PIIINP (1.9 ± 0.2 ng/ml) levels were significantly lower (P <0.0001) than in controls (5.5 ± 0.2, 3.9 ± 0.2 and 3.2 ± 0.2 ng/ml respectively). In preclinical Cushing's syndrome, serum BGP (2.5 ± 0.8 ng/ml), ICTP (2.2 ±).1 ng/ml) and PIIINP (2.2 ± 0.2 ng/ml) levels were significantly lower than in normal subjects (P <0.0001, P <0.0001 and P <0.02 respectively), being similar to those recorded in over Cushing's syndrome. In patients with adrenal incidentaloma, serum BGP (4.2 ± 0.5 ng/ml) and ICTP (2.9 ± 0.2 ng/ml) levels were significantly lower than those found in controls (P <0.05 and P <0.001 respectively), while serum PIIINP levels (3.6 ± 0.2 ng/ml) did not differ from those of normals. In particular, 9/35 patients with adrenal incidentaloma had markedly depressed BGP levels (
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U2 - 10.1530/eje.0.1380146
DO - 10.1530/eje.0.1380146
M3 - Article
C2 - 9506857
AN - SCOPUS:0031911847
VL - 138
SP - 146
EP - 152
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 2
ER -