Evaluation of mean platelet volume as a predictive marker for cancer-associated venous thromboembolism during chemotherapy

Patrizia Ferroni, Fiorella Guadagni, Silvia Riondino, Ilaria Portarena, Sabrina Mariotti, Francesca La Farina, Giovanni Davì, Mario Roselli

Research output: Contribution to journalArticlepeer-review

Abstract

Mean platelet volume has been proposed as a predictor for venous thromboembolism in cancer. We, therefore, investigated the effects of different anti-cancer drugs on mean platelet volume in order to assess its possible value in the risk prediction of a first thromboembolic episode in cancer outpatients during treatment. Pre-treatment mean platelet volumes were retrospectively evaluated in 589 ambulatory patients at the beginning of a new chemotherapy regimen. Moreover, serial changes were evaluated at baseline and before each chemotherapy cycle on 385 of the 589 patients who consented to have additional blood withdrawals during treatment. Cox proportional hazards survival analysis demonstrated a 2.7 hazard ratio (P=0.01) of developing a first venous thromboembolic episode during chemotherapy for patients with baseline mean platelet volumes below the 10th percentile (

Original languageEnglish
Pages (from-to)1638-1644
Number of pages7
JournalHaematologica
Volume99
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

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