Ten patients (5 women, 5 men; aged 14-25) with papulo-pustular acne vulgaris were treated with a standard spray preparation of meclocycline (Mecloderm Antiacne*) every 12 hours from Day 1 to Day 10. Skin samples from the same area of the forehead were taken at Time -10 (before treatment), Time 0 (under observation, no treatment) and Time +11 (after 10 days' treatment). The cutaneous microbic index (IMC) was determined for each sample to give the average bacteria per cm2 of skin examined. Before treatment (Times -10 and 0) there were great variations in the number of aerobes and anaerobes present in the samples. After 10 days of treatment (at Time +11) there was a reduction in the aerobes present in nine of the 10 patients, and in all 10 patients no anaerobes were cultured. In Patient No. 7, after 10 days of treatment, Staph. epidermidis and Ps. aeruginosa were still present, but with no anaerobes. There was clear clinical amelioration in eight of the 10 patients with fair improvement in the other two, with disappearance of pustules and a sharp decrease of papulae at the end of treatment.
|Number of pages||8|
|Journal||Clinical Trials Journal|
|Publication status||Published - 1988|
- Acne vulgaris
ASJC Scopus subject areas
- Pharmacology (medical)