Evaluation of molecular prognostic and predictive factors: An important step towards personalised treatment in non small cell lung cancer

Alfredo Tartarone, Rose Lerose, Giuseppina Gallucci, Raffaele Ardito, Michele Aieta

Research output: Contribution to journalArticle

Abstract

Treatment for patients with advanced NSCLC generally consists of chemotherapy, but response rates are modest and recurrence occurs for most patients after standard first-line platinum-based doublet therapy. Tailoring therapy to individual patient according to certain prognostic and predictive factors has the potential to improve outcome in NSCLC. This review focuses on the most important molecular prognostic and/or predictive factors in the treatment of advanced NSCLC; considering these molecular features, we also suggest a molecularbased treatment algorithm.

Original languageEnglish
Pages (from-to)1599-1605
Number of pages7
JournalMedical Oncology
Volume29
Issue number3
DOIs
Publication statusPublished - Sep 2012

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Keywords

  • ALK fusion oncogenes
  • Breast cancer susceptibility gene 1
  • Epidermal growth factor receptor
  • Excision repair cross-complementation 1
  • Molecular-based treatment algorithm
  • Non small cell lung cancer
  • Ribonucleotide reductase M1
  • Thymidylate synthase

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Hematology

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