Evaluation of needle biopsy as a potential risk factor for local recurrence of Wilms tumour in the SIOP WT 2001 trial

Sabine Irtan, Harm Van Tinteren, Norbert Graf, Marry M. van den Heuvel-Eibrink, Hugo Heij, Christophe Bergeron, Beatriz de Camargo, Tomas Acha, Filippo Spreafico, Gordan Vujanic, Mark Powis, Bruce Okoye, Jim Wilde, Jan Godzinski, Kathy Pritchard-Jones

Research output: Contribution to journalArticle

Abstract

Rationale: The impact of biopsying Wilms tumour (WT)at diagnosis on assigning the tumour stage and recommended treatment remains controversial. To address this important question, we analysed the potential association of all types of biopsy with local recurrence in patients treated in the SIOP WT 2001 trial, where needle biopsy was permitted without ‘upstaging’ the tumour to stage III. Only open biopsy required treatment as stage III. Methods: Among 2971 patients with unilateral WT (stages I-IV), 420 relapsed (139 local). Risk factors for recurrence were analysed by Cox proportional hazard methods. Results: Biopsy was performed in 969 of 2971 (33%)patients (64% cutting needle, 30% fine needle aspiration [FNA]and 6% open biopsy). Biopsied patients were older, with larger tumours and a greater proportion with high-risk histology. In multivariate analysis that included all factors associated with local recurrence in univariate analysis, only high-risk histology (hazard ratio [HR]= 2.32; 95% confidence interval [CI]: 1.58–3.42, p=<0.0001), age≥2 years (HR = 2.24; 95% CI: 1.22–4.09, p = 0.01)and preoperative tumour volume (HR = 1.07 per 100 ml; 95% CI: 1.02–1.12, p = 0.01)were significant. The HR for the association of local recurrence and event-free and overall survival with biopsy was not significant (HR = 1.4; 95% CI: 0.9–2.17, p = 0.13; HR = 1.1; 95% CI: 0.85–1.42, p = 0.46 and HR = 1.13; 95% CI: 0.79–1.62, p = 0.51, respectively). These results were not materially different whether FNA or open biopsy were included in the biopsy group or not. Conclusions: This post hoc analysis provides some reassurance that needle biopsy is not an independent adverse factor for either local recurrence or survival after adjustment for all relevant risk factors. Needle biopsy should not be an automatic criterion to ‘upstage’ WT.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalEuropean Journal of Cancer
Volume116
DOIs
Publication statusPublished - Jul 2019

Keywords

  • Biopsy
  • Local relapse
  • SIOP WT 2001
  • Wilms tumour

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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