Evaluation of O-[11C]methyl-L-tyrosine and O-[ 18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET

Kiichi Ishiwata, Kazunori Kawamura, Wei Fang Wang, Shozo Furumoto, Kazuo Kubota, Claudio Pascali, Anna Bogni, Ren Iwata

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the potential of O-[11C]methyl-L-tyrosine and O-[18 F]fluoromethyl-L-tyrosine as positron-emitting tracers for tumor imaging. The two tracers had similar distribution patterns in rats bearing AH109A hepatoma, with pancreas and, on a lesser extent, AH109A showing the highest uptake. Uptake of both tracers in the AH109A and uptake ratios of AH109A-to-tissues (with the exception of AH109A-to-bone) gradually increased for 60 min. O-[11C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[ 18F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging.

Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalNuclear Medicine and Biology
Volume31
Issue number2
DOIs
Publication statusPublished - Feb 2004

Keywords

  • O-[C]methyl-L-tyrosine
  • O-[F]fluoromethyl-L- tyrosine
  • Positron emission tomography
  • Tumor imaging

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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