Evaluation of olfactory dysfunction in neurodegenerative diseases

Marina Barresi, Rosella Ciurleo, Sabrina Giacoppo, Valeria Foti Cuzzola, Debora Celi, Placido Bramanti, Silvia Marino

Research output: Contribution to journalArticle

Abstract

It is known that the olfactory dysfunction is involved in various neurological diseases, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, Huntington's disease and motor neuron disease. In particular, the ability to identify and discriminate the odors, as well as the odor threshold, can be altered in these disorders. These changes often occur as early manifestation of the pathology and they are not always diagnosed on time. The aim of this review is to summarize the major neurological diseases which are preceded or accompanied by olfactory dysfunction. In addition, new instrumental approaches, such as psychophysical testing, olfactory event-related potentials (OERPs) and functional magnetic resonance imaging (fMRI) measurements, supported by olfactometer for the stimuli delivery, and their combination in evaluation of olfactory function will be discussed. In particular, OERPs and fMRI might to be good candidates to become useful additional tools in clinical protocols for early diagnosis of neurological diseases.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalJournal of the Neurological Sciences
Volume323
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2012

Fingerprint

Neurodegenerative Diseases
Evoked Potentials
Magnetic Resonance Imaging
Motor Neuron Disease
Aptitude
Huntington Disease
Clinical Protocols
Multiple Sclerosis
Parkinson Disease
Early Diagnosis
Alzheimer Disease
Pathology
Odorants

Keywords

  • Alzheimer's disease
  • Functional magnetic resonance imaging
  • Huntington's disease
  • Motor neuron disease
  • Multiple sclerosis
  • Olfactory dysfunction
  • Olfactory event-related potentials
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Evaluation of olfactory dysfunction in neurodegenerative diseases. / Barresi, Marina; Ciurleo, Rosella; Giacoppo, Sabrina; Foti Cuzzola, Valeria; Celi, Debora; Bramanti, Placido; Marino, Silvia.

In: Journal of the Neurological Sciences, Vol. 323, No. 1-2, 15.12.2012, p. 16-24.

Research output: Contribution to journalArticle

Barresi, Marina ; Ciurleo, Rosella ; Giacoppo, Sabrina ; Foti Cuzzola, Valeria ; Celi, Debora ; Bramanti, Placido ; Marino, Silvia. / Evaluation of olfactory dysfunction in neurodegenerative diseases. In: Journal of the Neurological Sciences. 2012 ; Vol. 323, No. 1-2. pp. 16-24.
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