Evaluation of plasmatic ANP levels in subjects affected by essential arterial hypertension and in a group of patients undergoing dialysis

R. Antonicelli, M. Melappioni, G. Campanari, F. Foschi, N. Panichi, E. Paciaroni

Research output: Contribution to journalArticle

Abstract

In the first part of this study we selected 24 hypertensive subjects (11 males, 13 females, mean age 55.4 ± 10.2 years) affected by essential arterial hypertension (EAH). Eleven people (5 males, 6 females, mean age 21.6 ± 9.5 years) had one or two hypertensive parents. Seventeen subjects (8 males, 9 females, mean age 56.4 ± 5.9 years) were the control group. Plasmatic ANP was measured using the RIA method, after extracting the peptide on Sep-Pak C18 cartridges. The results show the following ANP values: healthy control subjects 27.6 ± 8.6 pg/ml; offspring of essentially hypertensive subjects 25.6 ± 7.7 pg/ml; essentially hypertensive subjects 45.5 ± 24.9* pg/ml *(P <0.005). In the second part of our study, we evaluated the plasma levels of this hormone in a group of subjects undergoing dialysis. The group consisted of 21 subjects (12 males, 9 females, mean age 63.1 ± 10.5 years), 11 of whom were affected by EAH. ANP evaluation was done during the dialysis after a "long" dialytic interval of three days. Both groups showed a noticeable increase in ANP levels, even if the hypertensive group had overall higher values (254.5 ± 134.9 pg/ml, vs. 188.7 ± 113.7 pg/ml). All subjects, after dialysis, had ANP values significantly lower than the initial ones.

Original languageEnglish
JournalInternational Journal of Cardiology
Volume25
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1989

Fingerprint

Atrial Natriuretic Factor
Dialysis
Healthy Volunteers
Parents
Essential Hypertension
Hormones
Control Groups
Peptides

Keywords

  • Atrial natriuretic peptide
  • Dialysis
  • Essential arterial hypertension
  • Volume expansion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evaluation of plasmatic ANP levels in subjects affected by essential arterial hypertension and in a group of patients undergoing dialysis. / Antonicelli, R.; Melappioni, M.; Campanari, G.; Foschi, F.; Panichi, N.; Paciaroni, E.

In: International Journal of Cardiology, Vol. 25, No. SUPPL. 1, 1989.

Research output: Contribution to journalArticle

@article{2bf4be0c7d8c43fba4d35bc1a3e0379d,
title = "Evaluation of plasmatic ANP levels in subjects affected by essential arterial hypertension and in a group of patients undergoing dialysis",
abstract = "In the first part of this study we selected 24 hypertensive subjects (11 males, 13 females, mean age 55.4 ± 10.2 years) affected by essential arterial hypertension (EAH). Eleven people (5 males, 6 females, mean age 21.6 ± 9.5 years) had one or two hypertensive parents. Seventeen subjects (8 males, 9 females, mean age 56.4 ± 5.9 years) were the control group. Plasmatic ANP was measured using the RIA method, after extracting the peptide on Sep-Pak C18 cartridges. The results show the following ANP values: healthy control subjects 27.6 ± 8.6 pg/ml; offspring of essentially hypertensive subjects 25.6 ± 7.7 pg/ml; essentially hypertensive subjects 45.5 ± 24.9* pg/ml *(P <0.005). In the second part of our study, we evaluated the plasma levels of this hormone in a group of subjects undergoing dialysis. The group consisted of 21 subjects (12 males, 9 females, mean age 63.1 ± 10.5 years), 11 of whom were affected by EAH. ANP evaluation was done during the dialysis after a {"}long{"} dialytic interval of three days. Both groups showed a noticeable increase in ANP levels, even if the hypertensive group had overall higher values (254.5 ± 134.9 pg/ml, vs. 188.7 ± 113.7 pg/ml). All subjects, after dialysis, had ANP values significantly lower than the initial ones.",
keywords = "Atrial natriuretic peptide, Dialysis, Essential arterial hypertension, Volume expansion",
author = "R. Antonicelli and M. Melappioni and G. Campanari and F. Foschi and N. Panichi and E. Paciaroni",
year = "1989",
doi = "10.1016/0167-5273(89)90088-0",
language = "English",
volume = "25",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Evaluation of plasmatic ANP levels in subjects affected by essential arterial hypertension and in a group of patients undergoing dialysis

AU - Antonicelli, R.

AU - Melappioni, M.

AU - Campanari, G.

AU - Foschi, F.

AU - Panichi, N.

AU - Paciaroni, E.

PY - 1989

Y1 - 1989

N2 - In the first part of this study we selected 24 hypertensive subjects (11 males, 13 females, mean age 55.4 ± 10.2 years) affected by essential arterial hypertension (EAH). Eleven people (5 males, 6 females, mean age 21.6 ± 9.5 years) had one or two hypertensive parents. Seventeen subjects (8 males, 9 females, mean age 56.4 ± 5.9 years) were the control group. Plasmatic ANP was measured using the RIA method, after extracting the peptide on Sep-Pak C18 cartridges. The results show the following ANP values: healthy control subjects 27.6 ± 8.6 pg/ml; offspring of essentially hypertensive subjects 25.6 ± 7.7 pg/ml; essentially hypertensive subjects 45.5 ± 24.9* pg/ml *(P <0.005). In the second part of our study, we evaluated the plasma levels of this hormone in a group of subjects undergoing dialysis. The group consisted of 21 subjects (12 males, 9 females, mean age 63.1 ± 10.5 years), 11 of whom were affected by EAH. ANP evaluation was done during the dialysis after a "long" dialytic interval of three days. Both groups showed a noticeable increase in ANP levels, even if the hypertensive group had overall higher values (254.5 ± 134.9 pg/ml, vs. 188.7 ± 113.7 pg/ml). All subjects, after dialysis, had ANP values significantly lower than the initial ones.

AB - In the first part of this study we selected 24 hypertensive subjects (11 males, 13 females, mean age 55.4 ± 10.2 years) affected by essential arterial hypertension (EAH). Eleven people (5 males, 6 females, mean age 21.6 ± 9.5 years) had one or two hypertensive parents. Seventeen subjects (8 males, 9 females, mean age 56.4 ± 5.9 years) were the control group. Plasmatic ANP was measured using the RIA method, after extracting the peptide on Sep-Pak C18 cartridges. The results show the following ANP values: healthy control subjects 27.6 ± 8.6 pg/ml; offspring of essentially hypertensive subjects 25.6 ± 7.7 pg/ml; essentially hypertensive subjects 45.5 ± 24.9* pg/ml *(P <0.005). In the second part of our study, we evaluated the plasma levels of this hormone in a group of subjects undergoing dialysis. The group consisted of 21 subjects (12 males, 9 females, mean age 63.1 ± 10.5 years), 11 of whom were affected by EAH. ANP evaluation was done during the dialysis after a "long" dialytic interval of three days. Both groups showed a noticeable increase in ANP levels, even if the hypertensive group had overall higher values (254.5 ± 134.9 pg/ml, vs. 188.7 ± 113.7 pg/ml). All subjects, after dialysis, had ANP values significantly lower than the initial ones.

KW - Atrial natriuretic peptide

KW - Dialysis

KW - Essential arterial hypertension

KW - Volume expansion

UR - http://www.scopus.com/inward/record.url?scp=0024820879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024820879&partnerID=8YFLogxK

U2 - 10.1016/0167-5273(89)90088-0

DO - 10.1016/0167-5273(89)90088-0

M3 - Article

C2 - 2533581

AN - SCOPUS:0024820879

VL - 25

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - SUPPL. 1

ER -