TY - JOUR
T1 - Evaluation of positive surgical margins in patients undergoing robot-assisted and open radical prostatectomy according to preoperative risk groups
AU - Suardi, Nazareno
AU - Dell'Oglio, Paolo
AU - Gallina, Andrea
AU - Gandaglia, Giorgio
AU - Buffi, Nicolò
AU - Moschini, Marco
AU - Fossati, Nicola
AU - Lughezzani, Giovanni
AU - Karakiewicz, Pierre I.
AU - Freschi, Massimo
AU - Lucianò, Roberta
AU - Shariat, Shahrokh F.
AU - Guazzoni, Giorgio
AU - Gaboardi, Franco
AU - Montorsi, Francesco
AU - Briganti, Alberto
PY - 2015/4/27
Y1 - 2015/4/27
N2 - Objectives: Recent studies showed that robot-assisted radical prostatectomy (RARP) represents an oncologically safe procedure in patients with prostate cancer (PCa), where the rate of positive surgical margins (PSMs) might be lower in patients treated with RARP as compared with that of those undergoing the open approach (open RP [ORP]). The aim of this study is to analyze the rate of PSMs according to preoperative risk groups in a large cohort of patients treated with RARP and ORP in a single institution with standardized surgical technique and pathological examination. Materials and methods: We evaluated 6,194 consecutive patients with PCa undergoing either ORP (71.1%) or RARP (28.9%) between 1992 and 2014. Logistic regression analyses were used to test the association between type of surgery and PSMs in each preoperative risk group (low vs. intermediate vs. high) after adjusting for confounders. Results: Overall, 21.6% patients had PSMs. RARP was associated with a lower rate of PSMs in low-risk (11.5 vs. 15.4%, P = 0.01), intermediate-risk (18.9 vs. 23.5%, P = 0.008), and high-risk patients (19.7 vs. 30.1%, P
AB - Objectives: Recent studies showed that robot-assisted radical prostatectomy (RARP) represents an oncologically safe procedure in patients with prostate cancer (PCa), where the rate of positive surgical margins (PSMs) might be lower in patients treated with RARP as compared with that of those undergoing the open approach (open RP [ORP]). The aim of this study is to analyze the rate of PSMs according to preoperative risk groups in a large cohort of patients treated with RARP and ORP in a single institution with standardized surgical technique and pathological examination. Materials and methods: We evaluated 6,194 consecutive patients with PCa undergoing either ORP (71.1%) or RARP (28.9%) between 1992 and 2014. Logistic regression analyses were used to test the association between type of surgery and PSMs in each preoperative risk group (low vs. intermediate vs. high) after adjusting for confounders. Results: Overall, 21.6% patients had PSMs. RARP was associated with a lower rate of PSMs in low-risk (11.5 vs. 15.4%, P = 0.01), intermediate-risk (18.9 vs. 23.5%, P = 0.008), and high-risk patients (19.7 vs. 30.1%, P
KW - Positive surgical margins
KW - Prostate cancer
KW - Robot-assisted radical prostatectomy
UR - http://www.scopus.com/inward/record.url?scp=84945565044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945565044&partnerID=8YFLogxK
U2 - 10.1016/j.urolonc.2015.08.019
DO - 10.1016/j.urolonc.2015.08.019
M3 - Article
AN - SCOPUS:84945565044
JO - Urologic Oncology
JF - Urologic Oncology
SN - 1078-1439
ER -