Evaluation of positive surgical margins in patients undergoing robot-assisted and open radical prostatectomy according to preoperative risk groups

Nazareno Suardi, Paolo Dell'Oglio, Andrea Gallina, Giorgio Gandaglia, Nicolò Buffi, Marco Moschini, Nicola Fossati, Giovanni Lughezzani, Pierre I. Karakiewicz, Massimo Freschi, Roberta Lucianò, Shahrokh F. Shariat, Giorgio Guazzoni, Franco Gaboardi, Francesco Montorsi, Alberto Briganti

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Recent studies showed that robot-assisted radical prostatectomy (RARP) represents an oncologically safe procedure in patients with prostate cancer (PCa), where the rate of positive surgical margins (PSMs) might be lower in patients treated with RARP as compared with that of those undergoing the open approach (open RP [ORP]). The aim of this study is to analyze the rate of PSMs according to preoperative risk groups in a large cohort of patients treated with RARP and ORP in a single institution with standardized surgical technique and pathological examination. Materials and methods: We evaluated 6,194 consecutive patients with PCa undergoing either ORP (71.1%) or RARP (28.9%) between 1992 and 2014. Logistic regression analyses were used to test the association between type of surgery and PSMs in each preoperative risk group (low vs. intermediate vs. high) after adjusting for confounders. Results: Overall, 21.6% patients had PSMs. RARP was associated with a lower rate of PSMs in low-risk (11.5 vs. 15.4%, P = 0.01), intermediate-risk (18.9 vs. 23.5%, P = 0.008), and high-risk patients (19.7 vs. 30.1%, P

Original languageEnglish
JournalUrologic Oncology: Seminars and Original Investigations
DOIs
Publication statusAccepted/In press - Apr 27 2015

Keywords

  • Positive surgical margins
  • Prostate cancer
  • Robot-assisted radical prostatectomy

ASJC Scopus subject areas

  • Oncology
  • Urology

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