Evaluation of response to chemotherapy in patients affected with non-small cell lung cancer by means of three tumour markers elaborated by discriminant analysis

G. Paone, G. De Angelis, S. Greco, L. Portalone, L. De Marchis, G. Galluccio, A. Taglienti, A. Bisetti, F. Ameglio

Research output: Contribution to journalArticle

Abstract

Chemotherapy is the most effective treatment for inoperable patients (70%) affected with non-small cell lung cancer (NSCLC). The early detection of tumour progression is mandative in order to promptly shift these patients towards salvage or supportive therapy. The present authors investigated the clinical value of a panel of tumour markers, elaborated by means of discriminant analysis, as a follow-up indicator for the detection of tumour progression. The serum levels of tissue polypeptide antigen (TPA), CYFRA-21.1, neuron-specific enolase (NSE) and carcinoembryonic antigen (CEA) were determined before chemotherapy and after three cycles of treatment. Discriminant analysis generated a formula (canonic variable) which correctly classified the 87.8% of the 74 subjects (86.1% of the 36 progressive diseases and 89.5% of 38 non-progressive diseases). This approach produces an algorithm able to calculate a progression score in NSCLC patients which can be helpful for following-up care and therapy control of these patients.

Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalRespiratory Medicine
Volume91
Issue number6
DOIs
Publication statusPublished - Jul 1997

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Paone, G., De Angelis, G., Greco, S., Portalone, L., De Marchis, L., Galluccio, G., Taglienti, A., Bisetti, A., & Ameglio, F. (1997). Evaluation of response to chemotherapy in patients affected with non-small cell lung cancer by means of three tumour markers elaborated by discriminant analysis. Respiratory Medicine, 91(6), 361-367. https://doi.org/10.1016/S0954-6111(97)90063-9