Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis

A. Ravelli; S. Viola; B. Ramenghi; G. Di Fuccia; N. Ruperto; L. Zonta; A. Martini

doi:10.1007/BF02208347

Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis

A. Ravelli, S. Viola, B. Ramenghi, G. Di Fuccia, N. Ruperto, L. Zonta, A. Martini

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (≥50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p

Original language	English
Pages (from-to)	322-326
Number of pages	5
Journal	Clinical Rheumatology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1007/BF02208347
Publication status	Published - May 1995

Keywords

Functional Assessment
Functional Capacity
Juvenile Chronic Arthritis
Methotrexate

ASJC Scopus subject areas

Rheumatology
Immunology

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AU - Ramenghi, B.

AU - Di Fuccia, G.

AU - Ruperto, N.

AU - Zonta, L.

AU - Martini, A.

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