Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis

A. Ravelli, S. Viola, B. Ramenghi, G. Di Fuccia, N. Ruperto, L. Zonta, A. Martini

Research output: Contribution to journalArticlepeer-review


In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (≥50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p

Original languageEnglish
Pages (from-to)322-326
Number of pages5
JournalClinical Rheumatology
Issue number3
Publication statusPublished - May 1995


  • Functional Assessment
  • Functional Capacity
  • Juvenile Chronic Arthritis
  • Methotrexate

ASJC Scopus subject areas

  • Rheumatology
  • Immunology


Dive into the research topics of 'Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis'. Together they form a unique fingerprint.

Cite this