TY - JOUR
T1 - Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis
AU - Ravelli, A.
AU - Viola, S.
AU - Ramenghi, B.
AU - Di Fuccia, G.
AU - Ruperto, N.
AU - Zonta, L.
AU - Martini, A.
PY - 1995/5
Y1 - 1995/5
N2 - In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (≥50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p
AB - In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (≥50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p
KW - Functional Assessment
KW - Functional Capacity
KW - Juvenile Chronic Arthritis
KW - Methotrexate
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U2 - 10.1007/BF02208347
DO - 10.1007/BF02208347
M3 - Article
C2 - 7641510
AN - SCOPUS:0029017969
VL - 14
SP - 322
EP - 326
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
IS - 3
ER -