Abstract
In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (≥50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p
| Original language | English |
|---|---|
| Pages (from-to) | 322-326 |
| Number of pages | 5 |
| Journal | Clinical Rheumatology |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1995 |
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Keywords
- Functional Assessment
- Functional Capacity
- Juvenile Chronic Arthritis
- Methotrexate
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis. / Ravelli, A.; Viola, S.; Ramenghi, B.; Di Fuccia, G.; Ruperto, N.; Zonta, L.; Martini, A.
In: Clinical Rheumatology, Vol. 14, No. 3, 05.1995, p. 322-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis
AU - Ravelli, A.
AU - Viola, S.
AU - Ramenghi, B.
AU - Di Fuccia, G.
AU - Ruperto, N.
AU - Zonta, L.
AU - Martini, A.
PY - 1995/5
Y1 - 1995/5
N2 - In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (≥50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p
AB - In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (≥50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p
KW - Functional Assessment
KW - Functional Capacity
KW - Juvenile Chronic Arthritis
KW - Methotrexate
UR - http://www.scopus.com/inward/record.url?scp=0029017969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029017969&partnerID=8YFLogxK
U2 - 10.1007/BF02208347
DO - 10.1007/BF02208347
M3 - Article
VL - 14
SP - 322
EP - 326
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
IS - 3
ER -