Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis

A. Ravelli, S. Viola, B. Ramenghi, G. Di Fuccia, N. Ruperto, L. Zonta, A. Martini

Research output: Contribution to journalArticlepeer-review

Abstract

In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of methotrexate (MTX) in 29 children with JCA by assessing both the articular indices and a functional status measure. After 6 months of therapy, 15 of the 29 patients had a significant (≥50%) reduction in the number of joints with active arthritis and/or the articular severity score and were then judged as responders, while 14 did not respond to MTX. In the responder group, the median functional index score decreased from 17 (range: 13-27) at baseline to 13 (range: 13-15) at 6 months (p

Original languageEnglish
Pages (from-to)322-326
Number of pages5
JournalClinical Rheumatology
Volume14
Issue number3
DOIs
Publication statusPublished - May 1995

Keywords

  • Functional Assessment
  • Functional Capacity
  • Juvenile Chronic Arthritis
  • Methotrexate

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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