Evaluation of S-[11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites

S. P. Hume, A. A. Lammertsma, C. J. Bench, V. W. Pike, C. Pascali, J. E. Cremer, R. J. Dolan

Research output: Contribution to journalArticlepeer-review

Abstract

The biologically active S-enantiomer of [N-methyl-11C]citalopram was evaluated as a radioligand for in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60-120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.

Original languageEnglish
Pages (from-to)851-855
Number of pages5
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume19
Issue number8
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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