Evaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C measurement in acromegaly

M. Losa, R. Oeckler, J. Schopohl, O. A. Muller, J. Alba-Lopez, K. Von Werder

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Abstract

A series of 29 previously untreated patients with acromegaly underwent transsphenoidal adenomectomy. Pre- and postoperative evaluation consisted of measuring growth hormone (GH) secretory dynamics during an oral glucose tolerance test (OGTT), the insulin hypoglycemia test, and the thyrotropin- and gonadotropin-releasing hormone (TRH/GnRH) test, and by obtaining the basal somatomedin-C level. After surgery, clinical and biochemical amelioration was achieved in all but two patients. In the whole group, basal GH and somatomedin-C levels decreased from a mean (± standard error of the mean) of 52.3 ± 12.7 to 11.1 ± 6.3 ng/ml and from 7.6 ± 0.7 to 2.5 ± 0.5 U/ml, respectively. Application of different criteria of cure revealed that 19 patients (66%) had basal GH levels below 5 ng/ml, 17 patients (59%) had normal somatomedin-C values, 16 patients (55%) had complete GH suppression (

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalJournal of Neurosurgery
Volume70
Issue number4
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Losa, M., Oeckler, R., Schopohl, J., Muller, O. A., Alba-Lopez, J., & Von Werder, K. (1989). Evaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C measurement in acromegaly. Journal of Neurosurgery, 70(4), 561-567.