Evaluation of serum anti-Mullerian hormone levels to assess the ovarian reserve in women with severe endometriosis

Arianna Pacchiarotti, Paola Frati, Giusi Natalia Milazzo, Angelica Catalano, Vincenzo Gentile, Massimo Moscarini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective The aim of this study was to measure anti-Mullerian hormone (AMH) serum levels in women with severe endometriosis, in order to demonstrate the effect of the disease on ovarian reserve. Study design Prospective case-control study. One hundred and ninety-five patients were enrolled: 130 fertile patients (group A) and 65 patients with stage III and IV endometriosis, diagnosed by laparoscopy and histological examination (group B). AMH serum levels were measured in both groups and were compared using Student's t-test. Results The two groups were homogenous for main demographic data. Group B had statistically significantly lower mean AMH serum levels (0.97 ± 0.59 ng/ml) than group A (1.72 ± 0.63 ng/ml) (p = 0.001). Conclusions This study is a demonstration of the damage of endometriosis on ovarian reserve, leading to a form of incipient ovarian failure, which is considered as an early sign of advanced ovarian depletion in young women. These findings suggest that AMH could be used in the follow-up of patients with endometriosis, in order to assess promptly the decrease of ovarian reserve.

Original languageEnglish
Pages (from-to)62-64
Number of pages3
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume172
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Anti-Mullerian hormone
  • Endometriosis
  • Ovarian failure
  • Ovarian reserve

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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