Evaluation of serum biomarkers in nutritional disorders: Glycated apolipoprotein B, fasting serum glucose, fructosamine, stable and labile glycated hemoglobin in diabetic and non-diabetic subjects

Giampietro De Michele, Mario Correale, Onofrio De Michele, Vito Guerra, Rosalba Mazzarelli, Giovanni Misciagna

Research output: Contribution to journalArticlepeer-review

Abstract

Glycated apolipoprotein B (ApoB-G), a non enzymatically glycated protein, has recently been associated with myocardial infarction. Our aim is to evaluate, in diabetic and non diabetic subjects, the relationship of ApoB-G with serum fasting glucose, fructosamine, stable and labile fractions of glycated hemoglobin (SHbA1c, LHbA1c, respectively) and insulin. The subjects were recruited from a previous study on ApoB-G and myocardial infarction: 141 of them were studied, 43 with and 98 without diabetes. ApoB-G was measured using a monoclonal antibody, and linear regression and correlation were used for statistical analysis of the data. ApoB-G was higher in diabetic than in non diabetic subjects. There was a statistically significant correlation of ApoB-G with triglycerides (r = 0.38, p = 0.01) in diabetic subjects, and with total proteins (r = 0.37, p = 0.0002), triglycerides (r = 0.34, p = 0.0007), and cholesterol (r = 0.23, p = 0.02) in non diabetic subjects. In the most parsimonious multiple linear regression model of ApoB-G on all the other serum variables, there was a statistically significant association of ApoB-G with triglycerides, in both diabetic and non diabetic subjects. The main results of this study suggest that serum ApoB-G is associated with serum triglycerides in both diabetic and non diabetic subjects.

Original languageEnglish
Pages (from-to)925-936
Number of pages12
JournalImmunopharmacology and Immunotoxicology
Volume30
Issue number4
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Fructosamine
  • Glycated apolipoprotein B
  • Labile glycated hemoglobin
  • Serum triglycerides
  • Stable glycated hemoglobin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

Fingerprint Dive into the research topics of 'Evaluation of serum biomarkers in nutritional disorders: Glycated apolipoprotein B, fasting serum glucose, fructosamine, stable and labile glycated hemoglobin in diabetic and non-diabetic subjects'. Together they form a unique fingerprint.

Cite this