Abstract
Serum fragments of cptokeratins 8 and 18 (CK 8/18) and squamous cell carcinoma antigen (SCC) were evaluated in 30 patients with stage I-III head and neck tumors, 35 patients with non-neoplastic lung diseases and 80 normal subjects (healthy blood donors). Serum concentrations of both markers were significantly higher in patients with cancer than in controls. For CK 8/18 the median values in normal subjects, non-neoplastic respiratory diseases and head and neck cancer were 0.64, 0.79 and 1.45 ng/mL, respectively. For SCC the results were 0.37, 0.75 and 0.96 ng/mL. No significant correlation was found between marker levels and tumor site and stage. At a specificity of 95% (determined in a group of subjects including healthy blood donors and patients with benign diseases) the sensitivity of CK 8/18 was 56.6% versus 47% for SCC. Despite the low sensitivity of single marker determination, combined measurement of CK 8/18 and SCC increases the sensitivity to 73% with a specificity of 90%.
| Original language | English |
|---|---|
| Pages (from-to) | 395-400 |
| Number of pages | 6 |
| Journal | Journal of Experimental and Clinical Cancer Research |
| Volume | 14 |
| Issue number | 4 |
| Publication status | Published - 1995 |
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Keywords
- CK 8/18
- Cytokeratins
- Head and neck cancer
- SCC antigen
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Evaluation of serum fragments of cytokeratins 8 and 18 compared with squamous cell carcinoma antigen (SCC) in patients with stage I-III head and neck tumors. / Seregni, E.; Massaron, S.; Calabrese, L.; Bombardieri, E.
In: Journal of Experimental and Clinical Cancer Research, Vol. 14, No. 4, 1995, p. 395-400.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of serum fragments of cytokeratins 8 and 18 compared with squamous cell carcinoma antigen (SCC) in patients with stage I-III head and neck tumors
AU - Seregni, E.
AU - Massaron, S.
AU - Calabrese, L.
AU - Bombardieri, E.
PY - 1995
Y1 - 1995
N2 - Serum fragments of cptokeratins 8 and 18 (CK 8/18) and squamous cell carcinoma antigen (SCC) were evaluated in 30 patients with stage I-III head and neck tumors, 35 patients with non-neoplastic lung diseases and 80 normal subjects (healthy blood donors). Serum concentrations of both markers were significantly higher in patients with cancer than in controls. For CK 8/18 the median values in normal subjects, non-neoplastic respiratory diseases and head and neck cancer were 0.64, 0.79 and 1.45 ng/mL, respectively. For SCC the results were 0.37, 0.75 and 0.96 ng/mL. No significant correlation was found between marker levels and tumor site and stage. At a specificity of 95% (determined in a group of subjects including healthy blood donors and patients with benign diseases) the sensitivity of CK 8/18 was 56.6% versus 47% for SCC. Despite the low sensitivity of single marker determination, combined measurement of CK 8/18 and SCC increases the sensitivity to 73% with a specificity of 90%.
AB - Serum fragments of cptokeratins 8 and 18 (CK 8/18) and squamous cell carcinoma antigen (SCC) were evaluated in 30 patients with stage I-III head and neck tumors, 35 patients with non-neoplastic lung diseases and 80 normal subjects (healthy blood donors). Serum concentrations of both markers were significantly higher in patients with cancer than in controls. For CK 8/18 the median values in normal subjects, non-neoplastic respiratory diseases and head and neck cancer were 0.64, 0.79 and 1.45 ng/mL, respectively. For SCC the results were 0.37, 0.75 and 0.96 ng/mL. No significant correlation was found between marker levels and tumor site and stage. At a specificity of 95% (determined in a group of subjects including healthy blood donors and patients with benign diseases) the sensitivity of CK 8/18 was 56.6% versus 47% for SCC. Despite the low sensitivity of single marker determination, combined measurement of CK 8/18 and SCC increases the sensitivity to 73% with a specificity of 90%.
KW - CK 8/18
KW - Cytokeratins
KW - Head and neck cancer
KW - SCC antigen
UR - http://www.scopus.com/inward/record.url?scp=0029564865&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029564865&partnerID=8YFLogxK
M3 - Article
VL - 14
SP - 395
EP - 400
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
SN - 0392-9078
IS - 4
ER -