Evaluation of serum fragments of cytokeratins 8 and 18 compared with squamous cell carcinoma antigen (SCC) in patients with stage I-III head and neck tumors

E. Seregni, S. Massaron, L. Calabrese, E. Bombardieri

Research output: Contribution to journalArticle

Abstract

Serum fragments of cptokeratins 8 and 18 (CK 8/18) and squamous cell carcinoma antigen (SCC) were evaluated in 30 patients with stage I-III head and neck tumors, 35 patients with non-neoplastic lung diseases and 80 normal subjects (healthy blood donors). Serum concentrations of both markers were significantly higher in patients with cancer than in controls. For CK 8/18 the median values in normal subjects, non-neoplastic respiratory diseases and head and neck cancer were 0.64, 0.79 and 1.45 ng/mL, respectively. For SCC the results were 0.37, 0.75 and 0.96 ng/mL. No significant correlation was found between marker levels and tumor site and stage. At a specificity of 95% (determined in a group of subjects including healthy blood donors and patients with benign diseases) the sensitivity of CK 8/18 was 56.6% versus 47% for SCC. Despite the low sensitivity of single marker determination, combined measurement of CK 8/18 and SCC increases the sensitivity to 73% with a specificity of 90%.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Volume14
Issue number4
Publication statusPublished - 1995

Fingerprint

Keratin-8
Keratin-18
Neck
Head
Blood Donors
Serum
Neoplasms
Healthy Volunteers
Tumor Biomarkers
Head and Neck Neoplasms
Lung Diseases
Reference Values
squamous cell carcinoma-related antigen

Keywords

  • CK 8/18
  • Cytokeratins
  • Head and neck cancer
  • SCC antigen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Evaluation of serum fragments of cytokeratins 8 and 18 compared with squamous cell carcinoma antigen (SCC) in patients with stage I-III head and neck tumors",
abstract = "Serum fragments of cptokeratins 8 and 18 (CK 8/18) and squamous cell carcinoma antigen (SCC) were evaluated in 30 patients with stage I-III head and neck tumors, 35 patients with non-neoplastic lung diseases and 80 normal subjects (healthy blood donors). Serum concentrations of both markers were significantly higher in patients with cancer than in controls. For CK 8/18 the median values in normal subjects, non-neoplastic respiratory diseases and head and neck cancer were 0.64, 0.79 and 1.45 ng/mL, respectively. For SCC the results were 0.37, 0.75 and 0.96 ng/mL. No significant correlation was found between marker levels and tumor site and stage. At a specificity of 95{\%} (determined in a group of subjects including healthy blood donors and patients with benign diseases) the sensitivity of CK 8/18 was 56.6{\%} versus 47{\%} for SCC. Despite the low sensitivity of single marker determination, combined measurement of CK 8/18 and SCC increases the sensitivity to 73{\%} with a specificity of 90{\%}.",
keywords = "CK 8/18, Cytokeratins, Head and neck cancer, SCC antigen",
author = "E. Seregni and S. Massaron and L. Calabrese and E. Bombardieri",
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T1 - Evaluation of serum fragments of cytokeratins 8 and 18 compared with squamous cell carcinoma antigen (SCC) in patients with stage I-III head and neck tumors

AU - Seregni, E.

AU - Massaron, S.

AU - Calabrese, L.

AU - Bombardieri, E.

PY - 1995

Y1 - 1995

N2 - Serum fragments of cptokeratins 8 and 18 (CK 8/18) and squamous cell carcinoma antigen (SCC) were evaluated in 30 patients with stage I-III head and neck tumors, 35 patients with non-neoplastic lung diseases and 80 normal subjects (healthy blood donors). Serum concentrations of both markers were significantly higher in patients with cancer than in controls. For CK 8/18 the median values in normal subjects, non-neoplastic respiratory diseases and head and neck cancer were 0.64, 0.79 and 1.45 ng/mL, respectively. For SCC the results were 0.37, 0.75 and 0.96 ng/mL. No significant correlation was found between marker levels and tumor site and stage. At a specificity of 95% (determined in a group of subjects including healthy blood donors and patients with benign diseases) the sensitivity of CK 8/18 was 56.6% versus 47% for SCC. Despite the low sensitivity of single marker determination, combined measurement of CK 8/18 and SCC increases the sensitivity to 73% with a specificity of 90%.

AB - Serum fragments of cptokeratins 8 and 18 (CK 8/18) and squamous cell carcinoma antigen (SCC) were evaluated in 30 patients with stage I-III head and neck tumors, 35 patients with non-neoplastic lung diseases and 80 normal subjects (healthy blood donors). Serum concentrations of both markers were significantly higher in patients with cancer than in controls. For CK 8/18 the median values in normal subjects, non-neoplastic respiratory diseases and head and neck cancer were 0.64, 0.79 and 1.45 ng/mL, respectively. For SCC the results were 0.37, 0.75 and 0.96 ng/mL. No significant correlation was found between marker levels and tumor site and stage. At a specificity of 95% (determined in a group of subjects including healthy blood donors and patients with benign diseases) the sensitivity of CK 8/18 was 56.6% versus 47% for SCC. Despite the low sensitivity of single marker determination, combined measurement of CK 8/18 and SCC increases the sensitivity to 73% with a specificity of 90%.

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