Evaluation of several immunological parameters in patients with aseptic loosening of hip arthroplasty.

D. Granchi, G. Ciapetti, S. Stea, D. Cavedagna, N. Bettini, T. Bianco, G. Fontanesi, A. Pizzoferrato

Research output: Contribution to journalArticlepeer-review

Abstract

The authors evaluated several immunological parameters in patients with loosened hip arthroplasty in order to determine the state of sensitization with regard to the metallic constituents of the prosthesis. The results obtained by in vivo epicutaneous testing did not reveal a correlation between loosening and sensitization, as the patch test was positive in only 1 out of 16 cases examined. An evaluation of the lymphocyte subpopulation on peripheral blood demonstrated that patients with prostheses in Cr, Co, Mo, Ni alloy present significant lymphopenia, with a reduction in subpopulations CD4 and CD8 and a decrease in in vitro cytotoxic activity. The meaning of these modifications could be interpreted to be either a toxic effect products released from the implant, or as the recruitment of lymphocytes in the site of loosening, due to lymphocyte sequestration phenomena consequent to a cell-mediated hypersensitivity reaction.

Original languageEnglish
Pages (from-to)399-408
Number of pages10
JournalLa Chirurgia degli organi di movimento
Volume80
Issue number4
Publication statusPublished - Oct 1995

Fingerprint Dive into the research topics of 'Evaluation of several immunological parameters in patients with aseptic loosening of hip arthroplasty.'. Together they form a unique fingerprint.

Cite this