Evaluation of short-and long-term response to treatment in GIMEMA protocol for acute myeloid leukaemia

I. Ardoino; F. Ambrogi; S. Iacobelli; P. Boracchi; G. Manikis; M. G. Kounelakis; M. Zervakis; P. J G Lisboa; P. Fazi; M. Vignetti; E. M. Biganzoli; A. Starita

doi:10.1504/IJBET.2010.032699

Evaluation of short-and long-term response to treatment in GIMEMA protocol for acute myeloid leukaemia

I. Ardoino, F. Ambrogi, S. Iacobelli, P. Boracchi, G. Manikis, M. G. Kounelakis, M. Zervakis, P. J G Lisboa, P. Fazi, M. Vignetti, E. M. Biganzoli, A. Starita

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Acute Myeloid Leukaemia (AML) is a haematologic malignancy. Despite of improvements in prognosis it is still a severe disease and only a minority of patients are cured. Recently, insights into specific cytogenetics and biological aberration involved in the leukaemogenesis process are the target of research. LAM-99P GIMEMA Protocol identifies treatment guidelines for AML in adults. A methodological approach is proposed, compounding different modelling techniques, to assess the prognostic relevance of clinical as well as biological markers with regard to clinical endpoint, such as the achievement of Complete Remission in the short-term and long-term survival taking into account competing risks.

Original language	English
Pages (from-to)	329-348
Number of pages	20
Journal	International Journal of Biomedical Engineering and Technology
Volume	3
Issue number	3-4
DOIs	https://doi.org/10.1504/IJBET.2010.032699
Publication status	Published - Apr 2010

Keywords

Acute myeloid leukaemia
AML
Competing risks
CR
Multinomial logistic regression
Support vector machines
Survival analysis

ASJC Scopus subject areas

Biomedical Engineering

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Ardoino, I., Ambrogi, F., Iacobelli, S., Boracchi, P., Manikis, G., Kounelakis, M. G., Zervakis, M., Lisboa, P. J. G., Fazi, P., Vignetti, M., Biganzoli, E. M., & Starita, A. (2010). Evaluation of short-and long-term response to treatment in GIMEMA protocol for acute myeloid leukaemia. International Journal of Biomedical Engineering and Technology, 3(3-4), 329-348. https://doi.org/10.1504/IJBET.2010.032699

Ardoino, I, Ambrogi, F, Iacobelli, S, Boracchi, P, Manikis, G, Kounelakis, MG, Zervakis, M, Lisboa, PJG, Fazi, P, Vignetti, M, Biganzoli, EM & Starita, A 2010, 'Evaluation of short-and long-term response to treatment in GIMEMA protocol for acute myeloid leukaemia', International Journal of Biomedical Engineering and Technology, vol. 3, no. 3-4, pp. 329-348. https://doi.org/10.1504/IJBET.2010.032699

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abstract = "Acute Myeloid Leukaemia (AML) is a haematologic malignancy. Despite of improvements in prognosis it is still a severe disease and only a minority of patients are cured. Recently, insights into specific cytogenetics and biological aberration involved in the leukaemogenesis process are the target of research. LAM-99P GIMEMA Protocol identifies treatment guidelines for AML in adults. A methodological approach is proposed, compounding different modelling techniques, to assess the prognostic relevance of clinical as well as biological markers with regard to clinical endpoint, such as the achievement of Complete Remission in the short-term and long-term survival taking into account competing risks.",

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AU - Ardoino, I.

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AU - Iacobelli, S.

AU - Boracchi, P.

AU - Manikis, G.

AU - Kounelakis, M. G.

AU - Zervakis, M.

AU - Lisboa, P. J G

AU - Fazi, P.

AU - Vignetti, M.

AU - Biganzoli, E. M.

AU - Starita, A.

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AB - Acute Myeloid Leukaemia (AML) is a haematologic malignancy. Despite of improvements in prognosis it is still a severe disease and only a minority of patients are cured. Recently, insights into specific cytogenetics and biological aberration involved in the leukaemogenesis process are the target of research. LAM-99P GIMEMA Protocol identifies treatment guidelines for AML in adults. A methodological approach is proposed, compounding different modelling techniques, to assess the prognostic relevance of clinical as well as biological markers with regard to clinical endpoint, such as the achievement of Complete Remission in the short-term and long-term survival taking into account competing risks.

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KW - AML

KW - Competing risks

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Evaluation of short-and long-term response to treatment in GIMEMA protocol for acute myeloid leukaemia

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Keywords

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