Evaluation of skin perfusion after nipple-sparing mastectomy by indocyanine green dye. Preliminary results

Francesca De Lorenzi, S. Yamaguchi, J. Y. Petit, M. Rietjens, C. Garusi, S. Martella, P. C. Rey, R. Gennari

Research output: Contribution to journalArticlepeer-review


The aim of the study was to investigate the blood supply of the normal nipple areola complex (NAC) and the spared areola complex after a nipple-sparing mastectomy using the analysis of the fluorescence from the indocianine green dye (ICG) injection. Between December 2002 and July 2003 we performed the ICG analysis in 10 cases of healthy breasts and in 9 patients after a nipple-sparing mastectomy and one patient after subcutaneous mastectomy. In all cases, the resulting fluorescence was measured in three different zones: nipple, areola, surrounding mammary skin. Three parameters of the fluorescence curve (slope, maximum intensity, time to achieve a maximum level) were recorded. On the healthy breast, the nipple showed a very high perfusion as compared to the other zones. On the contrary, after the mastectomy the fluorescent pattern was completely altered, being the perfusion of the nipple very low. In conclusion, these preliminary results confirm the applicability and the importance of the ICG technique for evaluating the perfusion of the healthy and spared areola after surgery. Because of the small number of patients further studies are needed.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalJournal of Experimental and Clinical Cancer Research
Issue number3
Publication statusPublished - Sep 2005


  • Indocyanine green
  • Nipple sparing mastectomy
  • Skin blood supply
  • Skin fluorescence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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