STELLENWERT DES TUMORMARKERS TAG-72 (CA 72-4) BEI DER PRIMARDIAGNOSTIK DES OVARIALKARZINOMS. EIN VERGLEICH MIT DEM ETABLIERTEN MARKER CA-125

Translated title of the contribution: Evaluation of TAG-72 (CA 72-4) serum marker in primary diagnosis in ovarian cancer - A comparison with CA-125

A. G. Zeimet, F. Guadagni, C. Marth, T. Amato, E. Muller-Holzner, O. Huter, G. Daxenbichler, O. Dapunt

Research output: Contribution to journalArticle

Abstract

The value of the TAG-72 (CA 72-4) serum marker in primary diagnosis was investigated in 110 patients with histologically diagnosed ovarian cancer. A reference group consisted of 103 patients with benign pelvic masses. Compared to the well-established CA-125, TAG-72 showed a low sensitivity of 42% in the detection of ovarian cancer. By contrast, when the cutoff level for TAG-72 was set at 6 U/ml, it showed a very high specificity of 99%. When the measurement of TAG-72 was combined to that of CA-125, improvements in both the specificity (as compared to a single CA-125 determination) and the sensitivity (as compared to a single TAG-72 assay) were observed. In such a combined assay, our results suggest that the best predictive value (positive and negative) was obtained if CA-125 is assigned a relatively high cut-off value (65 U/ml) in conjunction with a low cut-off level (3,2 U/ml or 4 U/ml) for TAG-72. In the present study, at threshold values of 65 U/ml respectively, a sensitivity of 86%, a specificity of 83% and a positive and negative predictive value of 85% were obtained. In mucinous carcinomas of the ovary, however, the additional TAG-72 determination did not lead to a better predictive power than did CA-125 measurement alone.

Original languageGerman
Pages (from-to)195-199
Number of pages5
JournalGeburtshilfe und Frauenheilkunde
Volume55
Issue number4
Publication statusPublished - 1995

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Ovarian Neoplasms
Biomarkers
Mucinous Adenocarcinoma
tumor-associated antigen 72
Ovary

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

STELLENWERT DES TUMORMARKERS TAG-72 (CA 72-4) BEI DER PRIMARDIAGNOSTIK DES OVARIALKARZINOMS. EIN VERGLEICH MIT DEM ETABLIERTEN MARKER CA-125. / Zeimet, A. G.; Guadagni, F.; Marth, C.; Amato, T.; Muller-Holzner, E.; Huter, O.; Daxenbichler, G.; Dapunt, O.

In: Geburtshilfe und Frauenheilkunde, Vol. 55, No. 4, 1995, p. 195-199.

Research output: Contribution to journalArticle

Zeimet, AG, Guadagni, F, Marth, C, Amato, T, Muller-Holzner, E, Huter, O, Daxenbichler, G & Dapunt, O 1995, 'STELLENWERT DES TUMORMARKERS TAG-72 (CA 72-4) BEI DER PRIMARDIAGNOSTIK DES OVARIALKARZINOMS. EIN VERGLEICH MIT DEM ETABLIERTEN MARKER CA-125', Geburtshilfe und Frauenheilkunde, vol. 55, no. 4, pp. 195-199.
Zeimet, A. G. ; Guadagni, F. ; Marth, C. ; Amato, T. ; Muller-Holzner, E. ; Huter, O. ; Daxenbichler, G. ; Dapunt, O. / STELLENWERT DES TUMORMARKERS TAG-72 (CA 72-4) BEI DER PRIMARDIAGNOSTIK DES OVARIALKARZINOMS. EIN VERGLEICH MIT DEM ETABLIERTEN MARKER CA-125. In: Geburtshilfe und Frauenheilkunde. 1995 ; Vol. 55, No. 4. pp. 195-199.
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AU - Guadagni, F.

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AU - Daxenbichler, G.

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