STELLENWERT DES TUMORMARKERS TAG-72 (CA 72-4) BEI DER PRIMARDIAGNOSTIK DES OVARIALKARZINOMS. EIN VERGLEICH MIT DEM ETABLIERTEN MARKER CA-125

Translated title of the contribution: Evaluation of TAG-72 (CA 72-4) serum marker in primary diagnosis in ovarian cancer - A comparison with CA-125

A. G. Zeimet, F. Guadagni, C. Marth, T. Amato, E. Muller-Holzner, O. Huter, G. Daxenbichler, O. Dapunt

Research output: Contribution to journalArticlepeer-review

Abstract

The value of the TAG-72 (CA 72-4) serum marker in primary diagnosis was investigated in 110 patients with histologically diagnosed ovarian cancer. A reference group consisted of 103 patients with benign pelvic masses. Compared to the well-established CA-125, TAG-72 showed a low sensitivity of 42% in the detection of ovarian cancer. By contrast, when the cutoff level for TAG-72 was set at 6 U/ml, it showed a very high specificity of 99%. When the measurement of TAG-72 was combined to that of CA-125, improvements in both the specificity (as compared to a single CA-125 determination) and the sensitivity (as compared to a single TAG-72 assay) were observed. In such a combined assay, our results suggest that the best predictive value (positive and negative) was obtained if CA-125 is assigned a relatively high cut-off value (65 U/ml) in conjunction with a low cut-off level (3,2 U/ml or 4 U/ml) for TAG-72. In the present study, at threshold values of 65 U/ml respectively, a sensitivity of 86%, a specificity of 83% and a positive and negative predictive value of 85% were obtained. In mucinous carcinomas of the ovary, however, the additional TAG-72 determination did not lead to a better predictive power than did CA-125 measurement alone.

Translated title of the contributionEvaluation of TAG-72 (CA 72-4) serum marker in primary diagnosis in ovarian cancer - A comparison with CA-125
Original languageGerman
Pages (from-to)195-199
Number of pages5
JournalGeburtshilfe und Frauenheilkunde
Volume55
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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