Abstract
The value of the TAG-72 (CA 72-4) serum marker in primary diagnosis was investigated in 110 patients with histologically diagnosed ovarian cancer. A reference group consisted of 103 patients with benign pelvic masses. Compared to the well-established CA-125, TAG-72 showed a low sensitivity of 42% in the detection of ovarian cancer. By contrast, when the cutoff level for TAG-72 was set at 6 U/ml, it showed a very high specificity of 99%. When the measurement of TAG-72 was combined to that of CA-125, improvements in both the specificity (as compared to a single CA-125 determination) and the sensitivity (as compared to a single TAG-72 assay) were observed. In such a combined assay, our results suggest that the best predictive value (positive and negative) was obtained if CA-125 is assigned a relatively high cut-off value (65 U/ml) in conjunction with a low cut-off level (3,2 U/ml or 4 U/ml) for TAG-72. In the present study, at threshold values of 65 U/ml respectively, a sensitivity of 86%, a specificity of 83% and a positive and negative predictive value of 85% were obtained. In mucinous carcinomas of the ovary, however, the additional TAG-72 determination did not lead to a better predictive power than did CA-125 measurement alone.
| Original language | German |
|---|---|
| Pages (from-to) | 195-199 |
| Number of pages | 5 |
| Journal | Geburtshilfe und Frauenheilkunde |
| Volume | 55 |
| Issue number | 4 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
STELLENWERT DES TUMORMARKERS TAG-72 (CA 72-4) BEI DER PRIMARDIAGNOSTIK DES OVARIALKARZINOMS. EIN VERGLEICH MIT DEM ETABLIERTEN MARKER CA-125. / Zeimet, A. G.; Guadagni, F.; Marth, C.; Amato, T.; Muller-Holzner, E.; Huter, O.; Daxenbichler, G.; Dapunt, O.
In: Geburtshilfe und Frauenheilkunde, Vol. 55, No. 4, 1995, p. 195-199.Research output: Contribution to journal › Article
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TY - JOUR
T1 - STELLENWERT DES TUMORMARKERS TAG-72 (CA 72-4) BEI DER PRIMARDIAGNOSTIK DES OVARIALKARZINOMS. EIN VERGLEICH MIT DEM ETABLIERTEN MARKER CA-125
AU - Zeimet, A. G.
AU - Guadagni, F.
AU - Marth, C.
AU - Amato, T.
AU - Muller-Holzner, E.
AU - Huter, O.
AU - Daxenbichler, G.
AU - Dapunt, O.
PY - 1995
Y1 - 1995
N2 - The value of the TAG-72 (CA 72-4) serum marker in primary diagnosis was investigated in 110 patients with histologically diagnosed ovarian cancer. A reference group consisted of 103 patients with benign pelvic masses. Compared to the well-established CA-125, TAG-72 showed a low sensitivity of 42% in the detection of ovarian cancer. By contrast, when the cutoff level for TAG-72 was set at 6 U/ml, it showed a very high specificity of 99%. When the measurement of TAG-72 was combined to that of CA-125, improvements in both the specificity (as compared to a single CA-125 determination) and the sensitivity (as compared to a single TAG-72 assay) were observed. In such a combined assay, our results suggest that the best predictive value (positive and negative) was obtained if CA-125 is assigned a relatively high cut-off value (65 U/ml) in conjunction with a low cut-off level (3,2 U/ml or 4 U/ml) for TAG-72. In the present study, at threshold values of 65 U/ml respectively, a sensitivity of 86%, a specificity of 83% and a positive and negative predictive value of 85% were obtained. In mucinous carcinomas of the ovary, however, the additional TAG-72 determination did not lead to a better predictive power than did CA-125 measurement alone.
AB - The value of the TAG-72 (CA 72-4) serum marker in primary diagnosis was investigated in 110 patients with histologically diagnosed ovarian cancer. A reference group consisted of 103 patients with benign pelvic masses. Compared to the well-established CA-125, TAG-72 showed a low sensitivity of 42% in the detection of ovarian cancer. By contrast, when the cutoff level for TAG-72 was set at 6 U/ml, it showed a very high specificity of 99%. When the measurement of TAG-72 was combined to that of CA-125, improvements in both the specificity (as compared to a single CA-125 determination) and the sensitivity (as compared to a single TAG-72 assay) were observed. In such a combined assay, our results suggest that the best predictive value (positive and negative) was obtained if CA-125 is assigned a relatively high cut-off value (65 U/ml) in conjunction with a low cut-off level (3,2 U/ml or 4 U/ml) for TAG-72. In the present study, at threshold values of 65 U/ml respectively, a sensitivity of 86%, a specificity of 83% and a positive and negative predictive value of 85% were obtained. In mucinous carcinomas of the ovary, however, the additional TAG-72 determination did not lead to a better predictive power than did CA-125 measurement alone.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029016380&partnerID=8YFLogxK
M3 - Articolo
C2 - 7789707
AN - SCOPUS:0029016380
VL - 55
SP - 195
EP - 199
JO - Geburtshilfe und Frauenheilkunde
JF - Geburtshilfe und Frauenheilkunde
SN - 0016-5751
IS - 4
ER -