TY - JOUR
T1 - Evaluation of Task-Related Brain Activity
T2 - Is There a Role for 18F FDG-PET Imaging?
AU - Chiaravalloti, Agostino
AU - Micarelli, Alessandro
AU - Ricci, Maria
AU - Pagani, Marco
AU - Ciccariello, Gabriele
AU - Bruno, Ernesto
AU - Alessandrini, Marco
AU - Schillaci, Orazio
PY - 2019
Y1 - 2019
N2 - Positron emission tomography (PET) with 2-[18F]-fluorodeoxyglucose (FDG) has been widely used for the evaluation of cortical glucose metabolism in several neurodegenerative disorders while its potential role in the evaluation of cortical and subcortical activity during a task in the healthy and pathological brain still remains to be a matter of debate. Few studies have been carried out in order to investigate the potential role of this radiotracer for the evaluation of brain glucose consumption during dynamic brain activation. The aim of this review is to provide a general overview of the applications of FDG-PET in the evaluation of cortical activation at rest and during tasks, describing first the physiological basis of FDG distribution in brain and its kinetic in vivo. An overview of the imaging protocols and image interpretation will be provided as well. As a last aspect, the results of the main studies in this field will be summarized and the results of PET findings performed in healthy subjects and patients suffering from various diseases will be reported.
AB - Positron emission tomography (PET) with 2-[18F]-fluorodeoxyglucose (FDG) has been widely used for the evaluation of cortical glucose metabolism in several neurodegenerative disorders while its potential role in the evaluation of cortical and subcortical activity during a task in the healthy and pathological brain still remains to be a matter of debate. Few studies have been carried out in order to investigate the potential role of this radiotracer for the evaluation of brain glucose consumption during dynamic brain activation. The aim of this review is to provide a general overview of the applications of FDG-PET in the evaluation of cortical activation at rest and during tasks, describing first the physiological basis of FDG distribution in brain and its kinetic in vivo. An overview of the imaging protocols and image interpretation will be provided as well. As a last aspect, the results of the main studies in this field will be summarized and the results of PET findings performed in healthy subjects and patients suffering from various diseases will be reported.
KW - Cerebral Cortex/diagnostic imaging
KW - Fluorodeoxyglucose F18/therapeutic use
KW - Humans
KW - Neurodegenerative Diseases/diagnostic imaging
KW - Positron-Emission Tomography
KW - Radiopharmaceuticals/therapeutic use
U2 - 10.1155/2019/4762404
DO - 10.1155/2019/4762404
M3 - Review article
C2 - 31355263
VL - 2019
SP - 4762404
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
ER -