Evaluation of technetium-99m-sestamibi lung uptake: Correlation with left ventricular function

R. Giubbini, R. Campini, E. Milan, O. Zoccarato, C. Orlandi, P. Rossini, P. Giannuzzi, G. La Canna, M. Galli

Research output: Contribution to journalArticlepeer-review


Lung uptake of 201Tl is a reliable marker of left ventricular dysfunction. The goal of our study was to establish whether the evaluation of lung-to-heart uptake ratios (LHR) with 99mTc-sestamibi imaging may provide valuable information. Methods: We studied 72 male subjects with recent anterior myocardial infarction undergoing 99mTc-sestamibi first-pass ventriculography and SPECT perfusion imaging. A group of 46 gender-matched subjects with low pre-test likelihood of CAD and normal exercise and rest 99mTc-sestamibi perfusion images was used as a control. The lung-to-heart count ratios (LHR) were calculated on planar projections from the sets of SPECT images. Results: Both groups were studied at rest and after a symptom- limited exercise tolerance test. In the control group a significant decrease in LHR was observed during stress (p <0.001). The infarcted group showed significantly higher LHR values both at rest and at stress. Exercise and rest LHR values did not differ significantly. A positive correlation was observed between LHR values and left ventricular ejection fraction at rest and stress. Conclusion: LHR, measured by 99mTc-sestamibi imaging, gives clinically useful information. Both resting and postexercise values are correlated with ejection fraction and should predict left ventricular dysfunction.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalJournal of Nuclear Medicine
Issue number1
Publication statusPublished - 1995


  • first-pass radionuclide ventriculography
  • lung uptake
  • myocardial infarction
  • technetium-99m-sestamibi
  • ventricular function

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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