Evaluation of the 5mg/g liver iron concentration threshold and its association with morbidity in patients with β-thalassemia intermedia

Khaled M. Musallam, Maria Domenica Cappellini, Ali T. Taher

Research output: Contribution to journalArticle

Abstract

Iron overload may still occur in transfusion-independent patients with β-thalassemia intermedia due to increased intestinal iron absorption. In this study, we evaluated the association between iron overload, using a liver iron concentration threshold of therapeutic significance (≥. 5. mg/g), and morbidity in 168 chelation naive patients with β-thalassemia intermedia. We demonstrated that patients with a liver iron concentration ≥. 5. mg/g have a significantly higher prevalence of several serious vascular and endocrine/bone morbidities than do patients with

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalBlood cells, molecules & diseases
Volume51
Issue number1
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Iron overload
  • Liver iron concentration
  • Morbidity
  • Thalassemia intermedia

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology
  • Cell Biology

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