Evaluation of the antihypertensive effect of once-a-day trandolapril by 24-hour ambulatory blood pressure monitoring

Giuseppe Mancia, Raffaele De Cesaris, Roberto Fogari, Salvatore Lattuada, Giuseppe Montemurro, Carlo Palombo, Carlo Porcellati, Giuseppe Ranieri, Franco Tettamanti, Paolo Verdecchia, Claudio Marelli, Stefano Omboni, Antonella Ravogli, Alberto Zanchetti

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Abstract

The aim of this study was to evaluate the effects of trandolapril on 24-hour blood pressure in patients with mild-to-moderate essential hypertension. After a washout period of 4 weeks, 42 patients were randomized to receive 2 mg of trandolapril once dairy and 20 to receive placebo in a double-blind fashion for 6 weeks. This was followed by a second washout period of 4 weeks. At the end of each period, clinic blood pressure was assessed at 24 hours after the last dose and 24-hour ambulatory blood pressure was measured noninvasively, taking blood pressure readings every 15 minutes during the day and every 20 minutes during the night. Two patients were dropped out before any blood pressure evaluation under treatment. Analysis of ambulatory blood pressure was performed in 48 patients who met the criteria for the minimal number of ambulatory blood pressure data (2 values per hour during the day and 1 value per hour in the night). In the trandolapril-treated group (n = 41) clinic systolic/diastolic blood pressures were 159.8 ± 2.0/ 102.4 ± 0.8, 146.8 ± 2.3/94.8 ± 1.1, and 155.7 ± 2.0/99.2 ± 0.7 mm Hg in the pretreatment, treatment, and post-treatment periods, respectively. The corresponding values for 24-hour mean blood pressure (n = 31) were 139.5 ± 1.9 91.2 ± 1.5, 131.0 ± 2.0 84.3 ± 1.2, and 139.7 ± 1.8 90.9 ± 1.1 mm Hg. The differences between the lower treatment, versus the higher pre- and post-treatment, values were all statistically significant (p <0.01). The trandolapril-induced blood pressure fall was similar during the day and night and statistically significant also during the last 4 hours of the 24-hour monitoring period (-6.6 ± 0.3 and -5.9 ± 0.2 mm Hg for systolic and diastolie blood pressure, respectively; p <0.05). Trandolapril did not affect clinic heart rate but significantly towered 24-hour heart rate values. In the placebo group the clinic (n = 19) and ambulatory (n = 17) blood pressure and heart rate values obtained at the end of the 3 periods were similar. Thus, at the dose of 2 mg once daily, trandolapril reduces blood pressure in mildto-moderate hypertensive patients. This antihypertensive effect is manifest throughout the 24 hours.

Original languageEnglish
JournalThe American Journal of Cardiology
Volume70
Issue number12
DOIs
Publication statusPublished - Oct 29 1992

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trandolapril
Ambulatory Blood Pressure Monitoring
Antihypertensive Agents
Blood Pressure
Heart Rate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Evaluation of the antihypertensive effect of once-a-day trandolapril by 24-hour ambulatory blood pressure monitoring. / Mancia, Giuseppe; De Cesaris, Raffaele; Fogari, Roberto; Lattuada, Salvatore; Montemurro, Giuseppe; Palombo, Carlo; Porcellati, Carlo; Ranieri, Giuseppe; Tettamanti, Franco; Verdecchia, Paolo; Marelli, Claudio; Omboni, Stefano; Ravogli, Antonella; Zanchetti, Alberto.

In: The American Journal of Cardiology, Vol. 70, No. 12, 29.10.1992.

Research output: Contribution to journalArticle

Mancia, G, De Cesaris, R, Fogari, R, Lattuada, S, Montemurro, G, Palombo, C, Porcellati, C, Ranieri, G, Tettamanti, F, Verdecchia, P, Marelli, C, Omboni, S, Ravogli, A & Zanchetti, A 1992, 'Evaluation of the antihypertensive effect of once-a-day trandolapril by 24-hour ambulatory blood pressure monitoring', The American Journal of Cardiology, vol. 70, no. 12. https://doi.org/10.1016/0002-9149(92)90273-2
Mancia, Giuseppe ; De Cesaris, Raffaele ; Fogari, Roberto ; Lattuada, Salvatore ; Montemurro, Giuseppe ; Palombo, Carlo ; Porcellati, Carlo ; Ranieri, Giuseppe ; Tettamanti, Franco ; Verdecchia, Paolo ; Marelli, Claudio ; Omboni, Stefano ; Ravogli, Antonella ; Zanchetti, Alberto. / Evaluation of the antihypertensive effect of once-a-day trandolapril by 24-hour ambulatory blood pressure monitoring. In: The American Journal of Cardiology. 1992 ; Vol. 70, No. 12.
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AU - Lattuada, Salvatore

AU - Montemurro, Giuseppe

AU - Palombo, Carlo

AU - Porcellati, Carlo

AU - Ranieri, Giuseppe

AU - Tettamanti, Franco

AU - Verdecchia, Paolo

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AU - Omboni, Stefano

AU - Ravogli, Antonella

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N2 - The aim of this study was to evaluate the effects of trandolapril on 24-hour blood pressure in patients with mild-to-moderate essential hypertension. After a washout period of 4 weeks, 42 patients were randomized to receive 2 mg of trandolapril once dairy and 20 to receive placebo in a double-blind fashion for 6 weeks. This was followed by a second washout period of 4 weeks. At the end of each period, clinic blood pressure was assessed at 24 hours after the last dose and 24-hour ambulatory blood pressure was measured noninvasively, taking blood pressure readings every 15 minutes during the day and every 20 minutes during the night. Two patients were dropped out before any blood pressure evaluation under treatment. Analysis of ambulatory blood pressure was performed in 48 patients who met the criteria for the minimal number of ambulatory blood pressure data (2 values per hour during the day and 1 value per hour in the night). In the trandolapril-treated group (n = 41) clinic systolic/diastolic blood pressures were 159.8 ± 2.0/ 102.4 ± 0.8, 146.8 ± 2.3/94.8 ± 1.1, and 155.7 ± 2.0/99.2 ± 0.7 mm Hg in the pretreatment, treatment, and post-treatment periods, respectively. The corresponding values for 24-hour mean blood pressure (n = 31) were 139.5 ± 1.9 91.2 ± 1.5, 131.0 ± 2.0 84.3 ± 1.2, and 139.7 ± 1.8 90.9 ± 1.1 mm Hg. The differences between the lower treatment, versus the higher pre- and post-treatment, values were all statistically significant (p <0.01). The trandolapril-induced blood pressure fall was similar during the day and night and statistically significant also during the last 4 hours of the 24-hour monitoring period (-6.6 ± 0.3 and -5.9 ± 0.2 mm Hg for systolic and diastolie blood pressure, respectively; p <0.05). Trandolapril did not affect clinic heart rate but significantly towered 24-hour heart rate values. In the placebo group the clinic (n = 19) and ambulatory (n = 17) blood pressure and heart rate values obtained at the end of the 3 periods were similar. Thus, at the dose of 2 mg once daily, trandolapril reduces blood pressure in mildto-moderate hypertensive patients. This antihypertensive effect is manifest throughout the 24 hours.

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